Human TRAIL R2/TNFRSF10B Alexa Fluor® 647-conjugated Antibody Summary
Accession # O14763
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Detection of TRAIL R2/TNFRSF10B in MDA‑MB‑231 Human Cell Line by Flow Cytometry.
Detection of TRAIL R2/TNFRSF10B in MDA‑MB‑231 Human Cell Line by Flow Cytometry.MDA‑MB‑231 human breast cancer cell line was stained with Mouse Anti-Human TRAIL R2/TNFRSF10B Alexa Fluor® 647‑conjugated Monoclonal Antibody (Catalog # FAB6311R, filled histogram) or isotype control antibody (Catalog # IC0041R, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: TRAIL R2/TNFRSF10B
Human TRAIL R2, also known as DR5, CD262, and TRICK 2, is a type 1 transmembrane TNFR family protein which serves as a receptor for TRAIL (APO2 Ligand). In the new TNF superfamily nomenclature, TRAIL R2 is referred to as TNFRSF10B. TRAIL R2 cDNA encodes a 440 amino acid (aa) residue precursor protein that contains extracellular cysteine-rich domains, a transmembrane domain and a cytoplasmic death domain. Among TNF receptor family proteins, TRAIL R2 is most closely related to TRAIL R1/DR4, a molecule with which it shares 55% aa sequence identity. Binding of trimeric TRAIL to TRAIL R2 induces apoptosis. The induction of apoptosis likely requires oligomerization of the receptor. The human TRAIL R2/Fc chimera neutralizes the ability of TRAIL to induce apoptosis. Besides TRAIL R2, an additional TRAIL R1/DR4 (which tranduces apoptosis signaling) and two TRAIL decoy receptors (which antagonize TRAIL-induced apoptosis) have been reported. Human and Mouse TNFRSF10B extracellular domains share <40% aa sequence identity.
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