TRAIL R2/TNFRSF10B: Products

TNF-related apoptosis-inducing ligand (TRAIL), also known as Apo-2 ligand and TNFSF10, is a type II transmembrane protein with a carboxy-terminal extracellular domain that exhibits homology to other TNF superfamily members.

TRAIL binds at least five different receptors: TRAIL R1 (DR4), R2 (DR5), R3 (DcR1), R4 (DcR2), and osteoprotegerin (OPG). TRAIL receptors all exhibit cysteine-rich repeats characteristic of the TNF receptor superfamily. TRAIL R1 and R2 are type 1 transmembrane proteins with intracellular death domains (DD) and, subsequently, have the ability to mediate TRAIL-induced apoptosis. The remaining receptors are decoys that may regulate TRAIL activity by competing for binding sites with TRAIL R1 and R2. TRAIL R3 is membrane-associated via GPI linkage. TRAIL R4 is a type 1 transmembrane receptor, but exhibits a truncated cytoplasmic domain. Like the active receptors TRAIL R1 and R2, OPG has a DD motif but is a soluble protein.

"TRAIL R2/TNFRSF10B" has 25 results in Products.
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Human Magnetic Luminex Assay 

Human TRAIL R2/TNFRSF10B Antibody 

CyTOF-ready, Flow

Mouse TRAIL R2/TNFRSF10B Antibody 

1 Image
B/N, CyTOF-ready, Flow, WB

Proteome Profiler Human Apoptosis Array Kit 

Contains 4 membranes - each spotted in duplicate with 35 different apoptosis antibodies

Bioymifi 

DR5 (TRAIL receptor) agonist; induces apoptosis

Proteome Profiler Human NFkB Pathway Array 

Contains 4 membranes-each spotted in duplicate with 41 different proteins and 4 serine or tyrosine phosphorylation sites antibodies

Proteome Profiler Mouse Apoptosis Array 

Contains 8 membranes - each spotted in duplicate with 21 different apoptosis antibodies
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