Human Tryptase  gamma -1/TPSG1 Antibody

Catalog # Availability Size / Price Qty
Product Details
Supplemental Products

Human Tryptase  gamma -1/TPSG1 Antibody Summary

Species Reactivity
Detects human Tryptase gamma ‑1/TPSG1 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant mouse (rm) MCPT-1, recombinant human (rh) Tryptase alpha, rmTryptase beta -1, rhTryptase beta -2, or rmTryptase-5 is observed.
Monoclonal Rat IgG2B Clone # 279005
Protein A or G purified from hybridoma culture supernatant
Mouse myeloma cell line NS0-derived recombinant human Tryptase gamma ‑1/TPSG1
Accession # Q9NRR2
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Western Blot
1 µg/mL
Recombinant Human Tryptase  gamma ‑1/TPSG1 (Catalog # 1667-SE)
25 µg/mL
Conditioned cell culture medium spiked with Recombinant Human Tryptase  gamma ‑1/TPSG1 (Catalog # 1667-SE), see our available Western blot detection antibodies

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Preparation and Storage

Reconstitute at 0.5 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Tryptase gamma-1/TPSG1

As mediators of inflammatory and allergic response, mast cells are found throughout the body concentrated near blood vessels in connective tissue and the mucous membranes of the respiratory and gastrointestinal tract (3). Upon activation, human mast cells release granules that are enriched with neutral serine proteases including tryptases, chymase and cathepsin G (4). Tryptase gamma -1, also called transmembrane tryptase, is encoded by TPSG1, one of many serine protease genes clustered in human chromosome 16p13.3 (5). Human Tryptase gamma ‑1 is synthesized as a 321 amino acid preproenzyme with a C-terminal transmembrane anchor (1, 2).

  1. Wong, G.W. et al. (1999) J. Biol. Chem. 274:30784.
  2. Caughey, G.H. et al. (2000) J. Immunol. 164:6566.
  3. Harris, J.L. et al. (2001) J. Biol. Chem. 276:34941.
  4. Miller, H.R.P. and A.D. Pemberton (2002) Immunology 105:375.
  5. Wong, G.W. et al. (2002) J. Biol. Chem. 277:41906.
Entrez Gene IDs
25823 (Human)
Alternate Names
EC 3.4.21; EC 3.4.21.-; gamma I; gamma II; lung tryptase; mast cell protease II; mast cell tryptase; PRSS31skin tryptase; Serine protease 31; TMTpituitary tryptase; TPSG1; Transmembrane tryptase; trpA; tryptase gamma 1; tryptase gamma I; tryptase gamma II; tryptase gamma; Tryptase gamma1; Tryptase gamma-1

Product Datasheets


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ExactaChIP Chromatin Immunoprecipitation Kits

Isotype Controls

Rat IgG2B Isotype Control


Reconstitution Buffers

Secondary Antibodies

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