UNC5H2/UNC5B is a transmembrane molecule that mediates axon repulsion and growth cone collapse through interactions with Netrin, Neogenin, and FLRT3. Its association with DCC switches the DCC-Netrin-1 response from attraction to repulsion. Outside the nervous system, UNC5H2 facilitates Netrin-1-mediated inhibition of capillary branching and leukocyte migration as well as Netrin-1-mediated promotion of osteoclast differentiation. It is downregulated in multiple cancers and inhibits tumor cell growth and invasion. It also plays a critical role in the development of atherosclerosis and the survival of renal tubular epithelial cells during acute kidney injury.
Human UNC5H2/UNC5B (NP_734465) VersaClone cDNA
R&D Systems | Catalog # RDC1777
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Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: UNC5H2/UNC5B
Long Name
Netrin Receptor UNC5B
Alternate Names
UNC5B
Gene Symbol
UNC5B
UniProt
Additional UNC5H2/UNC5B Products
Product Documents for Human UNC5H2/UNC5B (NP_734465) VersaClone cDNA
Certificate of Analysis
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Product Specific Notices for Human UNC5H2/UNC5B (NP_734465) VersaClone cDNA
For research use only
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