Human UNC5H2/UNC5B (NP_734465) VersaClone cDNA

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RDC1777
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Human UNC5H2/UNC5B (NP_734465) VersaClone cDNA Summary

Members of the UNC5H family are best known as receptors for the axon guidance molecule netrin. Structurally, UNC5Hs have two Ig and two thrombospondin type 1 domains in their extracellular region, and a conserved ZU-5 domain, a deleted in colorectal cancer (DCC)-binding domain, and a C-terminal death domain in their cytoplasmic region. In general, they mediate the chemorepulsive effects of netrin, while the other netrin receptor subtype, DCC, mediates attraction. Members of the UNC5H family have also been implicated as tumor suppressors and regulators of apoptosis.

Specifications

Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Human

Product Datasheets

Background: UNC5H2/UNC5B

Long Name
Netrin Receptor UNC5B
Entrez Gene IDs
219699 (Human); 60630 (Rat)
Alternate Names
p53RDL1; p53-regulated receptor for death and life protein 1; Protein unc-5 homolog 2; Protein unc-5 homolog B; transmembrane receptor Unc5H2; unc5 (C.elegans homolog) b; unc-5 homolog 2; unc-5 homolog B (C. elegans); UNC5B; UNC5H2; UNC5H2netrin receptor UNC5B

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