HX 531

Tocris Bioscience | Catalog # 3912

Potent RXR antagonist
Tocris Bioscience

Key Product Details

Description

Potent RXR antagonist
View all Retinoid X Receptor Antagonists »

Product Description

HX 531 is a potent RXR antagonist (IC50 = 18 nM). Promotes white and brown pre-adipocyte differentiation into white adipocytes. Also inhibits bexarotene-induced brown adipogenic reprogramming of myoblasts.

Product Specifications for HX 531

Molecular Weight

483.56

Formula

C29H29N3O4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

4-(7,8,9,10-Tetrahydro-5,7,7,10.10-pentamethyl-2-nitro-5H-benzo[b]naphtho[2,3-e][1,4]-diazepin-12-yl)-benzoic acid

CAS Number

188844-34-0

PubChem ID

11755040

InChI Key

SXKPGYKPQPYJER-UHFFFAOYSA-N

SMILES

CC1(C)C2=C(C=C(N(C)C(C=CC([N+]([O-])=O)=C5)=C5N=C3C4=CC=C(C(O)=O)C=C4)C3=C2)C(C)(C)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.67 20

Preparing Stock Solutions for HX 531

The following data is based on the product molecular weight 483.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 10.34 mL 51.70 mL 103.40 mL
1 mM 2.07 mL 10.34 mL 20.68 mL
2 mM 1.03 mL 5.17 mL 10.34 mL
10 mM 0.21 mL 1.03 mL 2.07 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 53 publications citing the usage of this product.

Product Documents for HX 531

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for HX 531

For research use only

Customer Reviews for HX 531 (1)

5 out of 5
1 Customer Rating
5 Stars
100%
4 Stars
0%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used HX 531?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card

Customer Images

Showing  1 - 1 of 1 review Showing All
Filter By:
Clear Filters X
  • Complete ablation of RA-induced transcription in MCF7
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: MCF7
    Verified Customer | Posted 11/02/2019
    No apoptosis has been observed in any of our cells lines at 1 uM
    HX531 was dissolved to a concentration of 20 mM in DMSO with no solubility issues. Retinoic acid (10 uM), DMSO, or RA + HX531 (1 uM) was added to MCF7 cells for 5 hours following by qPCR analysis of a reporter gene normalized to GAPDH levels. 1 uM of HX531 completely ablated RA induced gene transcription by qPCR. This inhibitor exhibited lower variability than AGN193109, however this was repeated only once, and both inhibitors could completely ablate activity, either alone or in combination. We also added retinal to confirm that our reporter activity was retinoic acid-specific.
    HX 531 3912

There are no reviews that match your criteria.

Showing  1 - 1 of 1 review Showing All