hh HX 531 (CAS 188844-34-0): R&D Systems
Catalog Number: 3912
Chemical Name: 4-(7,8,9,10-Tetrahydro-5,7,7,10.10-pentamethyl-2-nitro-5H-benzo[b]naphtho[2,3-e][1,4]-diazepin-12-yl)-benzoic acid
Biological Activity
Potent RXR antagonist (IC50 = 18 nM). Promotes white and brown pre-adipocyte differentiation into white adipocytes. Also inhibits bexarotene-induced brown adipogenic reprogramming of myoblasts.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Retinoid X receptor-antagonistic diazepinylbenzoic acids.
    Ebisawa et al.
    Chem.Pharm.Bull., 1999;47:1778
  2. Vitamin A active metabolite, all-trans retinoic acid, induces spinal cord sensitization. II. Effects after intrathecal administration.
    Alique et al.
    Br.J.Pharmacol., 2006;149:65
  3. Docosahexaenoic acid induces adipose differentiation-related protein through activation of retinoid X receptor in human choriocarcinoma BeWo cells.
    Suzuki et al.
    Biol.Pharm.Bull., 2009;32:1177
  4. Brown adipogenic reprogramming induced by a small molecule.
    Nie et al.
    Cell Rep., 2017;18:624

The citations listed below are publications that use Tocris products. Selected citations for HX 531 include:

2 Citations: Showing 1 - 2
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  1. Brown adipogenic reprogramming induced by a small molecule.
    Authors: Nie Et al.
    Cell.Rep. 2017;18:624
  2. The Crucial Involvement of Retinoid X Receptors in DDE Neurotoxicity.
    Authors: Wnuk Et al.
    PLoS Biol 2016;29:155

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