Catalog Number: 3912
Chemical Name: 4-(7,8,9,10-Tetrahydro-5,7,7,10.10-pentamethyl-2-nitro-5H-benzo[b]naphtho[2,3-e][1,4]-diazepin-12-yl)-benzoic acid
Biological Activity
Potent RXR antagonist (IC50 = 18 nM).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under licence.
Background References
  1. Retinoid X receptor-antagonistic diazepinylbenzoic acids.
    Ebisawa et al.
    Chem.Pharm.Bull., 1999;47:1778
  2. Vitamin A active metabolite, all-trans retinoic acid, induces spinal cord sensitization. II. Effects after intrathecal administration.
    Alique et al.
    Br.J.Pharmacol., 2006;149:65
  3. Docosahexaenoic acid induces adipose differentiation-related protein through activation of retinoid X receptor in human choriocarcinoma BeWo cells.
    Suzuki et al.
    Biol.Pharm.Bull., 2009;32:1177

The citations listed below are publications that use Tocris products. Selected citations for HX 531 include:

Showing Results 1 - 1 of 1

  1. The Crucial Involvement of Retinoid X Receptors in DDE Neurotoxicity.
    Authors: Wnuk Et al.
    PLoS Biol
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