Hyaluronan (Medium MW)

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Product Details
Citations (7)
Reviews (2)

Hyaluronan (Medium MW) Summary

Product Specifications

S. pyogenes fermentation-derived
Predicted Molecular Mass
75 - 350 kDa
289 kDa

Product Datasheets

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Formulation White odorless powder.
Reconstitution Hyaluronan can be reconstituted in aqueous solutions.
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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Background: Hyaluronan

Hyaluronan (HA), also known as hyaluronic acid or sodium hyaluronate, is a naturally occurring linear polymer of the repeating disaccharide structure: D-glucuronic acid-beta-1, 3-N-acetylglucosamine-beta-1,4 (1 - 3). It is a glycosaminoglycan (GAG) that is ubiquitously present in the extracellular matrix of all vertebrates and is also present in the capsule of some strains of Streptococci. Unlike other GAGs such as chondroitin sulfate, dermatan sulfate, and heparin sulfate, HA lacks sulfate groups. Except for the covalent binding with the heavy chain of inter-alpha-trypsin inhibitor (2), HA is not covalently associated with other proteins. Mammalian HA is synthesized by one of three distinct HA synthases (HAS1, 2, and 3), which are plasma membrane proteins with multiple transmembrane domains (1 - 4). As UDP-sugar substrates are added, the growing HA polymer continuously translocates across the membrane to the extracellular surface. The three HA synthases differ in their rates of synthesis and produce HA polymers with different chain lengths. Whereas HAS-2 produces high molecular weight (HMW) HA with an average mass of greater than 2000 kDa, HAS-1 and HAS-3 produce HA with a size distribution of 200 - 2000 kDa (4). HA is important for the maintenance of a highly hydrated extracellular matrix in tissues, which is involved in cell adhesion and supports cell migration. HA also exhibits diverse biological functions by interacting with a large number of hyaluronan-binding proteins and cell surface receptors (CD44, LYVE-1) (5). HA biological functions differ depending on the size of HA (3 - 7). Whereas HMW HA (> 500 kDa) is anti-angiogenic, anti-inflammatory and immunosuppressive, low molecular weight (LMW) HA (10 - 500 kDa) is highly angiogenic and pro-inflammatory. HA oligomers are anti-apoptotic and upregulate heat shock protein expression. HA turns over rapidly in mammals, via the concerted actions of a family of at least 5 hyaluronidases (8).

  1. Weigel, P.H. et al. (1997) J. Biol. Chem. 272:13997.
  2. Bost, F. et al. (1998) Eur. J. Biochem. 252:339.
  3. Stern, R. (2004) Eur. J. Cell Biol. 83:317.
  4. Itano, N. and K. Kimata (2002) IUBMB Life 54:195.
  5. Day, A.J. http://www.glycoforum.gr.jp/science/hyaluronan/HA16/HA16E.html.
  6. Powell, J.D. and M.R. Horton (2005) Immunol. Res. 32:207.
  7. Csoka, A.B. et al. (2001) Matrix Biol. 20:499.
  8. Turley, E.A. et al. (2002) J. Biol. Chem. 277:4589.
Alternate Names

Citations for Hyaluronan (Medium MW)

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

7 Citations: Showing 1 - 7
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  1. ROS-Mediated Fragmentation Alters the Effects of Hyaluronan on Corneal Epithelial Wound Healing
    Authors: Lin, X;Moreno, IY;Nguyen, L;Gesteira, TF;Coulson-Thomas, VJ;
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Bioassay
  2. Targeting Toll-like receptors with soluble Toll-like receptor 2 prevents peritoneal dialysis solution-induced fibrosis.
    Authors: Raby A, Gonzalez-Mateo G, Williams A, Topley N, Fraser D, Lopez-Cabrera M, Labeta M
    Kidney Int, 2018-05-31;94(2):346-362.
    Species: Human, Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Modulation of hyaluronan polymer size regulates proliferation of perimysial fibroblasts in thyroid eye disease
    Authors: R Ma, Q Li, Z Wang, Y Yuan, L Gan, J Qian
    Biochem. Biophys. Res. Commun., 2018-02-05;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Hyaluronan and proteoglycan link protein 1 (HAPLN1) activates bortezomib-resistant NF-?B activity and increases drug resistance in multiple myeloma
    Authors: M Huynh, C Pak, S Markovina, NS Callander, KS Chng, SM Wuerzberge, DD Bakshi, JA Kink, P Hematti, C Hope, F Asimakopou, L Rui, S Miyamoto
    J. Biol. Chem., 2017-12-26;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Extravillous trophoblast cell invasion is promoted by the CD44-hyaluronic acid interaction.
    Authors: Takahashi H, Takizawa T, Matsubara S, Ohkuchi A, Kuwata T, Usui R, Matsumoto H, Sato Y, Fujiwara H, Okamoto A, Suzuki M, Takizawa T
    Placenta, 2013-12-30;35(3):163-70.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Heterodimeric integrin complexes containing beta1-integrin promote internalization and lethality of anthrax toxin.
    Authors: Martchenko M, Jeong SY, Cohen SN
    Proc. Natl. Acad. Sci. U.S.A., 2010-08-16;107(35):15583-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  7. Identification of a novel chondroitin hydrolase in Caenorhabditis elegans.
    Authors: Kaneiwa T, Yamada S, Mizumoto S, Montano AM, Mitani S, Sugahara K
    J. Biol. Chem., 2008-04-04;283(22):14971-9.
    Species: Human
    Sample Types: Recombinant Protein


  1. Does R&D Systems® hyaluronan contain any chondroitin sulfate?

    • No, the hyaluronan is produced by microbial fermentation of Streptococcus pyogenes, which does not make chondroitin sulfate.

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Reviews for Hyaluronan (Medium MW)

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Hyaluronan (Medium MW)
By Timothy Audam on 10/20/2020
Application: Impact of HA on macrophage efferocytosis
Reason for Rating: Excellent product that is LPS free for immune studies.

Hyaluronan (Medium MW)
By Anonymous on 05/17/2016
Application: In vitro bioactivity in cell culture