I-BRD9

Tocris Bioscience | Catalog # 5591

Potent and selective BRD9 inhibitor
Tocris Bioscience

Key Product Details

Description

Potent and selective BRD9 inhibitor
View all Bromodomain Inhibitors »

Product Description

I-BRD9 is a potent and selective BRD9 inhibitor (pIC50 = 7.3). Exhibits >70-fold selectivity for BRD9 over a panel of 34 other bromodomains and >700-fold selectivity over the BET family. Downregulates CLEC1, DUSP6, FES and SAMSN1 genes in Kasumi-1 cells.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the I-BRD9 probe summary on the SGC website.

External Portal Information

Chemicalprobes.org

is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of I-BRD9 is reviewed on the chemical probes website.

Product Specifications for I-BRD9

Molecular Weight

497.55

Formula

C22H22F3N3O3S2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

5-Ethyl-4,5-dihydro-4-oxo-N-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-7-[3-(trifluoromethyl)phenyl]thieno[3,2-c]pyridine-2-carboximidamide

CAS Number

1714146-59-4

PubChem ID

91668541

InChI Key

WRUWGLUCNBMGPS-UHFFFAOYSA-N

SMILES

O=C1C2=C(SC(C(NC3CCS(CC3)(=O)=O)=N)=C2)C(C4=CC=CC(C(F)(F)F)=C4)=CN1CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.76 100

Preparing Stock Solutions for I-BRD9

The following data is based on the product molecular weight 497.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.01 mL 10.05 mL 20.10 mL
5 mM 0.40 mL 2.01 mL 4.02 mL
10 mM 0.20 mL 1.00 mL 2.01 mL
50 mM 0.04 mL 0.20 mL 0.40 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

Product Documents for I-BRD9

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for I-BRD9

For research use only

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