I-CBP 112

Tocris Bioscience | Catalog # 4891

Selective CBP/p300 BRD inhibitor
Tocris Bioscience
Discontinued Product
4891 has been discontinued. View all Bromodomain Inhibitors products.

Key Product Details

Description

Selective CBP/p300 BRD inhibitor
View all Bromodomain Inhibitors »

Product Description

I-CBP 112 is a CBP/p300 bromodomain inhibitor (IC50 values are 0.142-0.17 and 0.625 μM for CBP and p300 respectively). Selective for CBP and p300 over ATAD2, BAZ2B, BRD2(2), BRD4(1), PB1(5), PCAF, PHIP(2) and TIF1α bromodomains in a BLI assay. Accelerates FRAP recovery in cells at a concentration of 1 μM.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the I-CBP 112 probe summary on the SGC website.

External Portal Information

Chemicalprobes.org

is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of I-CBP 112 is reviewed on the chemical probes website.

Product Specifications for I-CBP 112

Molecular Weight

468.59

Formula

C27H36N2O5

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

1-[7-(3,4-Dimethoxyphenyl)-9-[[(3S)-1-methylpiperidin-3-yl]methoxy]-2,3,4,5-tetrahydro-1,4-benzoxazepin-4-yl]propan-1-one

CAS Number

1640282-31-0

PubChem ID

90488984

InChI Key

YKNAKDFZAWQEEO-IBGZPJMESA-N

SMILES

COC(C(OC)=C1)=CC=C1C2=CC(OC[C@H]3CCCN(C)C3)=C(OCCN(C(CC)=O)C4)C4=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 100
DMSO 100

Preparing Stock Solutions for I-CBP 112

The following data is based on the product molecular weight 468.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.13 mL 10.67 mL 21.34 mL
5 mM 0.43 mL 2.13 mL 4.27 mL
10 mM 0.21 mL 1.07 mL 2.13 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for I-CBP 112

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for I-CBP 112

For research use only

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