Home / Bromodomain Inhibitors / I-CBP 112

I-CBP 112

4891 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4891/10
4891/50
I-CBP 112 | CAS No. 1640282-31-0 | Bromodomain Inhibitors
1 Image
Description: Selective CBP/p300 BRD inhibitor

Chemical Name: 1-[7-(3,4-Dimethoxyphenyl)-9-[[(3S)-1-methylpiperidin-3-yl]methoxy]-2,3,4,5-tetrahydro-1,4-benzoxazepin-4-yl]propan-1-one

Purity: ≥98%

Product Details
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

CBP/p300 bromodomain inhibitor (IC50 values are 0.142-0.17 and 0.625 μM for CBP and p300 respectively). Selective for CBP and p300 over ATAD2, BAZ2B, BRD2(2), BRD4(1), PB1(5), PCAF, PHIP(2) and TIF1α bromodomains in a BLI assay. Accelerates FRAP recovery in cells at a concentration of 1 μM.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of I-CBP 112 is reviewed on the chemical probes website.

Technical Data

M.Wt:
468.59
Formula:
C27H36N2O5
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1640282-31-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the I-CBP 112 probe summary on the SGC website.

Background References

  1. Bromodomains and their pharmacological inhibitors.
    Gallenkamp et al.
    ChemMedChem, 2014;9:438

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for I-CBP 112

There are currently no reviews for this product. Be the first to review I-CBP 112 and earn rewards!

Have you used I-CBP 112?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.