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I-CBP 112

4891 Datasheet / COA / SDS
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4891/10
4891/50
I-CBP 112 | CAS No. 1640282-31-0 | Bromodomain Inhibitors
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Description: Selective CBP/p300 BRD inhibitor

Chemical Name: 1-[7-(3,4-Dimethoxyphenyl)-9-[[(3S)-1-methylpiperidin-3-yl]methoxy]-2,3,4,5-tetrahydro-1,4-benzoxazepin-4-yl]propan-1-one

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

CBP/p300 bromodomain inhibitor (IC50 values are 0.142-0.17 and 0.625 μM for CBP and p300 respectively). Selective for CBP and p300 over ATAD2, BAZ2B, BRD2(2), BRD4(1), PB1(5), PCAF, PHIP(2) and TIF1α bromodomains in a BLI assay. Accelerates FRAP recovery in cells at a concentration of 1 μM.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of I-CBP 112 is reviewed on the chemical probes website.

Technical Data

Formula:
C27H36N2O5
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
Storage:
Store the unopened product at room temperature. Do not use past expiration date.
CAS No:
1640282-31-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the I-CBP 112 probe summary on the SGC website.

Background References

  1. Bromodomains and their pharmacological inhibitors.
    Gallenkamp et al.
    ChemMedChem, 2014;9:438

Product Datasheets

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