IC 261

Key Product Details

Product Description

IC 261 is an ATP-competitive casein kinase 1 (CK1) inhibitor. Displays >15 fold selectivity for CK1δ and CK1ε over CK1α (IC₅₀ values are approximately 1 μM for CK1δ and CK1ε and 16 μM for CK1α). Arrests cell cycle at postmitotic G₁ phase in cells expressing p53. Inhibits CK1 mediated phosphorylation of LRRK2 in cell lines.

Product Specifications for IC 261

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for IC 261

The following data is based on the product molecular weight 311.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.21 mL	16.06 mL	32.12 mL
5 mM	0.64 mL	3.21 mL	6.42 mL
10 mM	0.32 mL	1.61 mL	3.21 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Mashhoon Crystal structure of a conformation-selective casein kinase-1 inhibitor. J.Med.Chem. 2000 PMID: 10749871
• Chia Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7. Nat.Commun. 2014 PMID: 25500533
• Behrend IC261, a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects. Oncogene 2000 PMID: 11103931

Product Documents for IC 261