IC 261

Catalog # Availability Size / Price Qty
6676/5
6676/25
Cat.No. 6676 - IC 261 | C18H17NO4 | CAS No. 186611-52-9
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Description: CK1 inhibitor; displays selectivity for CK1δ and CK1ε

Chemical Name: 1,3-Dihydro-3-[(2,4,6-trimethoxyphenyl)methylene]-2H-indol-2-one

Purity: ≥98%

Product Details
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Biological Activity

ATP-competitive casein kinase 1 (CK1) inhibitor. Displays >15 fold selectivity for CK1δ and CK1ε over CK1α (IC50 values are approximately 1 μM for CK1δ and CK1ε and 16 μM for CK1α). Arrests cell cycle at postmitotic G1 phase in cells expressing p53. Inhibits CK1 mediated phosphorylation of LRRK2 in cell lines.

Technical Data

M.Wt:
311.33
Formula:
C18H17NO4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
186611-52-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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