ICA 121431

Key Product Details

Product Description

ICA 121431 is a potent and selective inhibitor of human Na_V1.3 and Na_V1.1 channels (IC₅₀ values are 13 and 23 nM respectively). Exhibits up to 1,000 fold selectivity against other TTX-sensitive or resistant sodium channels (IC₅₀ values are >10 μM for human Na_V1.5 and Na_V1.8 channels). Interacts with an inhibitory interaction site distinct from those bound by TTX and local anesthetic-like modulators.

Product Specifications for ICA 121431

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ICA 121431

The following data is based on the product molecular weight 449.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.22 mL	11.12 mL	22.24 mL
5 mM	0.44 mL	2.22 mL	4.45 mL
10 mM	0.22 mL	1.11 mL	2.22 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 18 publications citing the usage of this product.

• McCormack Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels. Proc.Natl.Acad.Sci. 2013 PMID: 23818614

Product Documents for ICA 121431