Potent and selective inhibitor of human NaV
1.3 and NaV
1.1 channels (IC50
values are 13 and 23 nM respectively). Exhibits up to 1,000 fold selectivity against other TTX-sensitive or resistant sodium channels (IC50
values are >10 μ
M for human NaV
1.5 and NaV
1.8 channels). Interacts with an inhibitory interaction site distinct from those bound by TTX and local anesthetic-like modulators.
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All Tocris products are intended for laboratory research use only.
Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels.
McCormack et al.