Chemical Name: α-Phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]benzeneacetamide
Biological ActivityICA 121431 is a potent and selective inhibitor of human NaV1.3 and NaV1.1 channels (IC50 values are 13 and 23 nM respectively). Exhibits up to 1,000 fold selectivity against other TTX-sensitive or resistant sodium channels (IC50 values are >10 μM for human NaV1.5 and NaV1.8 channels). Interacts with an inhibitory interaction site distinct from those bound by TTX and local anesthetic-like modulators.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels.
McCormack et al.
Citation for ICA 121431
The citations listed below are publications that use Tocris products. Selected citations for ICA 121431 include:
1 Citation: Showing 1 - 1
Control of Neurotransmission by NaV1.7 in Human, Guinea Pig, and Mouse Airway Parasympathetic Nerves.
Authors: Kocmalova Et al.
J Pharmacol Exp Ther 2017;361:172
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