Cooling agent that activates the novel cold receptors TRPM8 (CMR1) and TRPA1 (ANKTM1/TRPN1), members of the TRP ion channel family. Induces currents in CMR1-expressing HEK 293 cells (EC50
= 0.36 μ
M) more potently than menthol or low temperatures. Produces "wet shakes" in vivo
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Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay.
Behrendt et al.
Identification of a cold receptor reveals a general role for TRP channels in thermosensation.
McKemy et al.
ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures.
Story et al.
AG-3-5: a chemical producing sensations of cold.
Wei et al.
The citations listed below are publications that use Tocris products. Selected citations for Icilin include:
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