Chemical Name: 3,4-Dihydro-3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-(1H)-pyrimidin-2-one
Biological ActivityCooling agent that activates the novel cold receptors TRPM8 (CMR1) and TRPA1 (ANKTM1/TRPN1), members of the TRP ion channel family. Induces currents in CMR1-expressing HEK 293 cells (EC50 = 0.36 μM) more potently than menthol or low temperatures. Produces "wet shakes" in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay.
Behrendt et al.
Identification of a cold receptor reveals a general role for TRP channels in thermosensation.
McKemy et al.
ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures.
Story et al.
AG-3-5: a chemical producing sensations of cold.
Wei et al.
Citations for Icilin
The citations listed below are publications that use Tocris products. Selected citations for Icilin include:
5 Citations: Showing 1 - 5
Structural insights into TRPM8 inhibition and desensitization.
Authors: Diver Et al.
Inhibitory Interneurons That Express GFP in the PrP-GFP Mouse Spinal Cord Are Morphologically Heterogeneous, Innervated by Several Classes of Primary Afferent and Include Lamina I Projection Neurons among Their Postsynaptic Targets.
Authors: Ganley Et al.
Pharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in mice.
Authors: Knowlton Et al.
PLoS One 2011;6:e25894
PSA reduces prostate cancer cell motility by stimulating TRPM8 activity and plasma membrane expression.
Authors: Gkika Et al.
Respir Res 2010;29:4611
Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain.
Authors: Proudfoot Et al.
Curr Biol 2006;16:1591
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