Icilin

Catalog # Availability Size / Price Qty
1531/10
1531/50
Icilin | CAS No. 36945-98-9 | TRPA1 Agonists
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Description: Activates a novel cold receptor. Cooling agent
Alternative Names: AG 3-5

Chemical Name: 3,4-Dihydro-3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-(1H)-pyrimidin-2-one

Purity: ≥98%

Product Details
Citations (5)
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Biological Activity

Cooling agent that activates the novel cold receptors TRPM8 (CMR1) and TRPA1 (ANKTM1/TRPN1), members of the TRP ion channel family. Induces currents in CMR1-expressing HEK 293 cells (EC50 = 0.36 μM) more potently than menthol or low temperatures. Produces "wet shakes" in vivo.

Technical Data

M.Wt:
311.3
Formula:
C16H13N3O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
36945-98-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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