Icilin

Key Product Details

Product Description

Icilin is a cooling agent that activates the novel cold receptors TRPM8 (CMR1) and TRPA1 (ANKTM1/TRPN1), members of the TRP ion channel family. Induces currents in CMR1-expressing HEK 293 cells (EC₅₀ = 0.36 μM) more potently than menthol or low temperatures. Produces "wet shakes" in vivo.

Product Specifications for Icilin

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Icilin

The following data is based on the product molecular weight 311.30.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.21 mL	16.06 mL	32.12 mL
5 mM	0.64 mL	3.21 mL	6.42 mL
10 mM	0.32 mL	1.61 mL	3.21 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 49 publications citing the usage of this product.

• Diver Science.
• Wei AG-3-5: a chemical producing sensations of cold. J.Pharm.Pharmacol. 1983 PMID: 6131976
• McKemy Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 2002 PMID: 11882888
• Story ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 2003 PMID: 12654248
• Behrendt Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br.J.Pharmacol. 2004 PMID: 14757700

Product Documents for Icilin