Icilin

  ( 4 citations )    
Product Datasheet
Catalog Number:1531
Alternate Names:AG 3-5
Chemical Name:3,4-Dihydro-3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-(1H)-pyrimidin-2-one
Product Details
Citations (4)
Supplemental Products
Reviews
Biological Activity
Cooling agent that activates the novel cold receptors TRPM8 (CMR1) and TRPA1 (ANKTM1/TRPN1), members of the TRP ion channel family. Induces currents in CMR1-expressing HEK 293 cells (EC50 = 0.36 μM) more potently than menthol or low temperatures. Produces "wet shakes" in vivo.
Technical Data
  • M.Wt:
    311.3
  • Formula:
    C16H13N3O4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    36945-98-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
COA view current batch
or select another batch:
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Icilin include:

4 Citations: Showing 1 - 4
Filter your results:

  1. Inhibitory Interneurons That Express GFP in the PrP-GFP Mouse Spinal Cord Are Morphologically Heterogeneous, Innervated by Several Classes of Primary Afferent and Include Lamina I Projection Neurons among Their Postsynaptic Targets.
    Authors: Ganley Et al.
    Oncogene  2015;35:7626
  2. Pharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in mice.
    Authors: Knowlton Et al.
    PLoS One  2011;6:e25894
  3. PSA reduces prostate cancer cell motility by stimulating TRPM8 activity and plasma membrane expression.
    Authors: Gkika Et al.
    Respir Res  2010;29:4611
  4. Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain.
    Authors: Proudfoot Et al.
    Curr Biol  2006;16:1591

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used Icilin?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee