Human TRPM8 (Q7Z2W7) VersaClone cDNA

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R&D Systems VersaClone cDNA Plasmids
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Human TRPM8 (Q7Z2W7) VersaClone cDNA Summary


Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

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Background: TRPM8

TRPM8 functions as a cold receptor in sensory neurons but is also expressed in tissues not exposed to ambient temperatures, as well as in cancer tissues. TRPM8 is expressed in prostate and in most in prostate tumors. TRPM8 is also expressed in non-prostatic primary tumors such as colon, lung, breast and skin tumors. There are two shorter splice variants of TRPM8, termed short TRPM8a and short TRPM8 beta. Both variants are in a closed configuration with the C-terminal tail of the full-length TRPM8 channel, resulting in stabilization of its closed state and thus reducing both its cold sensitivity and activity. The sensation of coolness triggered by eucalyptol or menthol may be explained by the fact that menthol and cool temperatures sensations are detected by this protein.

Entrez Gene IDs
79054 (Human); 171382 (Mouse); 171384 (Rat)
Alternate Names
CMR1; Long transient receptor potential channel 6; LTRPC6; LTrpC-6; MGC2849; short form of the TRPM8 cationic channel; transient receptor potential cation channel, subfamily M, member 8; Transient receptor potential p8; transient receptor potential subfamily M member 8; TRPM8; TRPP8; trp-p8; TRPP8transient receptor potential cation channel subfamily M member 8

Citation for Human TRPM8 (Q7Z2W7) VersaClone cDNA

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Activation of host transient receptor potential (TRP) channels by praziquantel stereoisomers
    Authors: GS Gunaratne, NA Yahya, PI Dosa, JS Marchant
    PLoS Negl Trop Dis, 2018;12(4):e0006420.  2018


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