Idasanutlin

Catalog # Availability Size / Price Qty
6904/50
6904/10
Ubiquitin Ligase (E3) Inhibitors Small Molecule
1 Image
Description: Potent MDM2 inhibitor; inhibits MDM2-p53 interaction

Chemical Name: 4-[[[(2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxybenzoic acid

Purity: ≥98%

Product Details
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Biological Activity

Potent MDM2 inhibitor (IC50 = 6 nM in binding assay, and 30 nM in cancer cell proliferation assay). Induces p53 stabilisation, cell cycle arrest and apoptosis in cancer cells expression wildtype p53. Displays inhibition of tumor growth in the SJSA1 tumor xenograft model. Also inhibits MDR-1 at high concentrations.

Technical Data

M.Wt:
616.49
Formula:
C31H29Cl2F2N3O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1229705-06-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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