IDR 1002

Name: IDR 1002
Brand: Tocris Bioscience
SKU: 7866

Tocris Bioscience | Catalog # 7866

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Product Documents

Innate defence regulator peptide

Discontinued Product

7866 has been discontinued. View all Cytokine Compounds products.

Technical Data
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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Innate defence regulator peptide

View all Cytokine Compounds »

Product Description

IDR 1002 is an innate defence regulator peptide. It reduces bacterial burden and inflammatory responses in murine models of sinusitis infection and bacterial acute lung infection. It inhibits LPS-induced NF-κB and COX-2 and induces the phosphorylation/activation of p38, ERK1/2, MSK1, and CREB.

Product Specifications for IDR 1002

Molecular Weight

1652.06

Formula

C₇₉H₁₃₀N₂₆O₁₃

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

1224095-25-3

PubChem ID

166603919

InChI Key

SEBZWKNTKRJFDZ-BRVBZNILSA-N

SMILES

O=C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C(C)C)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C(C)C)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product.

Wuerth Characterization of host responses during pseudomonas aeruginosa acute infection in the lungs and blood and after treatment with the synthetic immunomodulatory peptide IDR-1002. Infect.Immun. 2018 PMID: 30323028
Huante-Mendoza Peptide IDR-1002 inhibits NF-κB nuclear translocation by inhibition of IκBα degradation and activates p38/ERK1/2-MSK1-dependent CREB phosphorylation in macrophages stimulated with lipopolysaccharide. Front.Immunol. 2016 PMID: 27933067
Alford Murine model of sinusitis infection for screening antimicrobial and immunomodulatory therapies. Front.Cell.Infect.Microbiol. 2021 PMID: 33777834

Product Documents for IDR 1002

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for IDR 1002

For research use only

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