IEM 1754 dihydrobromide

Key Product Details

Product Description

IEM 1754 dihydrobromide is a voltage-dependent open-channel blocker of AMPA receptors. Selective between subtypes; blocks GluA2 subunit-lacking (Ca²⁺-permeable) receptors more potently than GluA2-containing receptors. Also potently blocks NMDA receptor channels. Less sensitive than IEM 1460 (Cat. No. 1460) at a holding potential between -40 and -80mV.

Product Specifications for IEM 1754 dihydrobromide

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for IEM 1754 dihydrobromide

The following data is based on the product molecular weight 412.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.43 mL	12.13 mL	24.26 mL
5 mM	0.49 mL	2.43 mL	4.85 mL
10 mM	0.24 mL	1.21 mL	2.43 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Tikhonov Voltage-dependent block of native AMPA receptor channels by dicationic compounds. Br.J.Pharmacol. 2000 PMID: 10694232
• Magazanik Block of open channels of recombinant AMPA receptors and native AMPA/kainate receptors by adamantane derivatives. J.Physiol. 1997 PMID: 9457643

Product Documents for IEM 1754 dihydrobromide