Catalog Number: 4199
Chemical Name: N-(Tricyclo[,7]dec-1-ylmethyl)-1,5-pentanediamine dihydrobromide
Biological Activity
Voltage-dependent open-channel blocker of AMPA receptors. Selective between subtypes; blocks GluR2 subunit-lacking (Ca2+-permeable) receptors more potently than GluR2-containing receptors. Also potently blocks NMDA receptor channels. Less sensitive than IEM 1460 (Cat. No. 1460) at a holding potential between -40 and -80mV.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 50 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Block of open channels of recombinant AMPA receptors and native AMPA/kainate receptors by adamantane derivatives.
    Magazanik et al.
    J.Physiol., 1997;505:655
  2. Voltage-dependent block of native AMPA receptor channels by dicationic compounds.
    Tikhonov et al.
    Br.J.Pharmacol., 2000;129:265
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