IEM 1754 dihydrobromide
Chemical Name: N-(Tricyclo[126.96.36.199,7]dec-1-ylmethyl)-1,5-pentanediamine dihydrobromide
Biological ActivityVoltage-dependent open-channel blocker of AMPA receptors. Selective between subtypes; blocks GluA2 subunit-lacking (Ca2+-permeable) receptors more potently than GluA2-containing receptors. Also potently blocks NMDA receptor channels. Less sensitive than IEM 1460 (Cat. No. 1460) at a holding potential between -40 and -80mV.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Block of open channels of recombinant AMPA receptors and native AMPA/kainate receptors by adamantane derivatives.
Magazanik et al.
Voltage-dependent block of native AMPA receptor channels by dicationic compounds.
Tikhonov et al.
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