IGFBP-6 Antibody Pair [HRP]

Novus Biologicals | Catalog # NBP2-79629

Novus Biologicals
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Key Product Details

Assay Type

Sandwich ELISA

Assay Range

7.8-500 pg/ml (example only; lot dependent)

Sensitivity

7.8 pg/ml (example only; lot dependent)

Reactivity

Human
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Product Specifications

Description

Solid Phase sandwich ELISA for the quantitative determination of Human IGFBP-6.

Sample Volume Required

100 ul

Conjugate

HRP

Scientific Data Images for IGFBP-6 Antibody Pair [HRP]

Sandwich ELISA: IGFBP-6 Antibody Pair [HRP] [NBP2-79629] - This standard curve is only for demonstration purposes. A standard curve should be generated for each assay.

Kit Contents for IGFBP-6 Antibody Pair [HRP]

  • Mouse Monoclonal Capture Antibody
  • Rabbit Monoclonal Detection Antibody (HRP-conjugated): (Catalog # NBP2-90157)
  • Standard

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Storage of components varies. See protocol for specific instructions.

Background: IGFBP-6

Data show that an increase in JNK activation in the presence of NFkappaB inhibition significantly increased the expression of IGFBP6. These studies provide evidence that over expression of IGFBP-6 suppresses human and murine osteoblast differentiation, that IGFBP-6 and LMP-1 physically interact, and supports the conclusion that this interaction may be functionally relevant. IGFBP-6 is the effector of tumor suppressor activity of SEMA3B. Observational study of gene-disease association. (HuGE Navigator) IGFBP-6 is translocated to the nucleus with functional consequences, and different members of the IGFBP family have specific nuclear import mechanisms. Toxic effect of TCDD on osteogenesis through altering IGFBP6 gene expression in osteoblasts is reported. p38 MAPK is involved in IGFBP-6-induced IGF-independent rhabdomyosarcoma cell migration. determination of blood levels in adult patients with severe liver disease before and after orthotopic liver transplantation. Inhibition of human osteoblast marker gene expression by retinoids is mediated in part by insulin-like growth factor binding protein-6. A close correlation exists between residues of the carboxyl-terminal domain of IGFBP6 undergoing conformational change in 15N NMR spectroscopy studies with those that disappeared or broadened upon insulin-like growth factor (IGF-II) binding. C-domain of IGFBP-6 consists of a thyroglobulin type 1 fold comprising an alpha-helix followed by a loop, a three-stranded antiparallel beta-sheet incorporating a second loop, and a disulfide-bonded flexible third loop. The expression of certain IGFBP is significantly altered in renal cell carcinoma. CCI-779 acts additively with IGFBP-6 to reduce rhabdomyosarcoma growth both in vitro and in vivo. may function as an antiproliferative molecule suppressing mitogenic effects of insulin-like growth factors on Malassez cells. The IGFBP-6 protein is synthesized as propeptides with a hydrophobic leader sequence, removal of which yields a mature protein composed of 3 recognizable domains of similar size. transgenic human IGFBP-6 mice may be considered a new tool for studies of the involvement of the brain IGF system in metabolism control and obesity.

Long Name

Insulin-like Growth Factor Binding Protein 6

Alternate Names

IGFBP6

Gene Symbol

IGFBP6

Additional IGFBP-6 Products

Product Documents for IGFBP-6 Antibody Pair [HRP]

Certificate of Analysis

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Product Specific Notices for IGFBP-6 Antibody Pair [HRP]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Antibody Pairs are guaranteed for 6 months from date of receipt.

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