IL‑28A/Interferon-lambda 2) is a type III interferon that is upregulated in response to viral infection. It acts primarily on epithelial cells through a receptor complex that contains IL-10 R beta and IL-28 R alpha/IFN-lambda R1. IL-28A promotes the Th1 polarization of dendritic cells in the airway (e.g. production of IL-12 p70 and IFN-gamma) and inhibits Th2 and Th17 mediated inflammation. In the liver, however, the IL-28A induced Th1 cytokine response contributes to inflammation in T cell mediated hepatitis. IL-28A additionally exhibits anti-tumor activity, in part by enhancing IL-12 dependent anti-tumor CTL responses. In contrast, it is upregulated in invasive bladder cancer where it promotes tumor cell migration.
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Mouse IL-28A/IFN-lambda 2 ELISA Kit (Colorimetric)
Novus Biologicals | Catalog # NBP3-54904
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Key Product Details
Sample Type & Volume Required Per Well
Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids (100 uL)
Sensitivity
6.3 pg/mL (example only; lot dependent)
Assay Range
15.625 - 1000 pg/mL (example only; lot dependent)
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Product Specifications
Assay Type
Sandwich ELISA
Kit Type
ELISA Kit (Colorimetric)
Species
Mouse
Description
Assay Length: 4.5 hours
Precision
Intra-Assay Precision (Precision within an assay) %CV 10 (example only; lot dependent)
Inter-Assay Precision (Precision between assays) %CV 12 (example only; lot dependent)
Kit Contents for Mouse IL-28A/IFN-lambda 2 ELISA Kit (Colorimetric)
- Pre-coated 96T strip plate, Plate sealer for 96 wells, Standard, Diluent Buffer, Detection Reagent A, Detection Reagent B, TMB Substrate, Stop Solution, Wash Buffer (30 x concentrate), Instruction manual
Preparation and Storage
Stability & Storage
Storage of components varies. See protocol for specific instructions.
Background: IL-28A/IFN-lambda 2
Long Name
Interleukin 28A
Alternate Names
IFN-lambda 2, IL28A
Gene Symbol
IFNL3
Additional IL-28A/IFN-lambda 2 Products
Product Documents for Mouse IL-28A/IFN-lambda 2 ELISA Kit (Colorimetric)
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for Mouse IL-28A/IFN-lambda 2 ELISA Kit (Colorimetric)
This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.
Related Research Areas
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Protocols
Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.
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- Troubleshooting Guide: ELISA
- View all Protocols, Troubleshooting, Illustrated assays and Webinars
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Associated Pathways
