Chemical Name: 3-[2-[(4-Fluorophenyl)methyl]imidazo[2,1-b]thiazol-6-yl]-2H-1-benzopyran-2-one
Biological ActivityiMDK is a suppressor of endogenous midkine (MDK) expression. Inhibits PI 3-K signaling in H441 lung adenocarcinoma cells. Selectively attenuates growth of MDK-expressing cancer cells. Induces apoptosis in H441 cells and suppresses growth of H441 cell xenografts in mice.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibition of the growth factor MDK/Midkine by a novel small molecule compound to treat non-small cell lung cancer.
Hao et al.
PLoS ONE, 2013;8:e71093
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