Suppressor of endogenous midkine (MDK) expression. Inhibits PI 3-K signaling in H441 lung adenocarcinoma cells. Selectively attenuates growth of MDK-expressing cancer cells. Induces apoptosis in H441 cells and suppresses growth of H441 cell xenografts in mice.
Soluble to 5 mM in DMSO
Store at +4°C
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Inhibition of the growth factor MDK/Midkine by a novel small molecule compound to treat non-small cell lung cancer.
Hao et al.
PLoS ONE, 2013;8:e71093