Imetit dihydrobromide

Key Product Details

Product Description

Imetit dihydrobromide is an an extremely potent, high affinity agonist at H₃ and H₄ receptors (K_i values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC₅₀ of 25 nM. Centrally active following systemic administration.

Product Specifications for Imetit dihydrobromide

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Imetit dihydrobromide

The following data is based on the product molecular weight 332.06.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

5 4 3 2 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.01 mL	15.06 mL	30.12 mL
5 mM	0.60 mL	3.01 mL	6.02 mL
10 mM	0.30 mL	1.51 mL	3.01 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

• Garbarg S-[2-(4-Imidazolyl)ethyl]isothiourea, a highly specific and potent histamine H₃ receptor agonist. J.Pharmacol.Exp.Ther. 1992 PMID: 1383495
• Ling Histamine H₄ receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation. Br.J.Pharmacol. 2004 PMID: 15131002
• Farzin and Attarzadeh Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rats. Eur.J.Pharmacol. 2000 PMID: 10980276

Product Documents for Imetit dihydrobromide