Catalog Number: 0729
Chemical Name: 5-[2-(Imidazol-4-yl)ethyl]isothiourea dihydrobromide
Biological Activity
An extremely potent, high affinity agonist at H3 and H4 receptors (Ki values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC50 of 25 nM. Centrally active following systemic administration. Also available as part of the Histamine H3 Receptor Tocriset™.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rats.
    Farzin and Attarzadeh
    Eur.J.Pharmacol., 2000;404:169
  2. S-[2-(4-Imidazolyl)ethyl]isothiourea, a highly specific and potent histamine H3 receptor agonist.
    Garbarg et al.
    J.Pharmacol.Exp.Ther., 1992;263:304
  3. Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation.
    Ling et al.
    Br.J.Pharmacol., 2004;142:161

The citations listed below are publications that use Tocris products. Selected citations for Imetit dihydrobromide include:

Showing Results 1 - 2 of 2

  1. Histamine 3 receptor activation reduces the expression of neuronal angiotensin II type 1 receptors in the heart.
    Authors: Hashikawa-Hobara Et al.
    Evid Based Complement Alternat Med
  2. Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus.
    Authors: Yoshimoto Et al.
    Proc Natl Acad Sci U S A
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