IMP 2373

Key Product Details

Product Description

IMP 2373 is a pan-deubiquitinase (pan-DUB) activity-based probe with alkyne click handle. IMP 2373 interacts with more than 35 DUBs in diverse cell lines and across a range of non-toxic concentrations. IMP 2373 can be used to monitor changes in intracellular DUB activity in live cells during pharmacological inhibition and in vivo during MYC deregulation in a model of B cell lymphoma.

Product Specifications for IMP 2373

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for IMP 2373

The following data is based on the product molecular weight 360.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.77 mL	13.87 mL	27.75 mL
5 mM	0.55 mL	2.77 mL	5.55 mL
10 mM	0.28 mL	1.39 mL	2.77 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Conole Discovery of a potent Deubiquitinase (DUB) small-molecule activity-based probe enables broad spectrum DUB activity profiling in living cells. Angew Chem.Int.Ed.Engl. 2023 PMID: 37779326

Product Documents for IMP 2373