Deubiquitinating Enzyme Compounds

Deubiquitinating enzymes (DUBs) are a group of proteases that catalyze the cleavage of protein-ubiquitin bonds. By removing these modifications, DUBs counteract the activity of ubiquitin ligases, which add ubiquitin molecules to target proteins.

USPs are the largest and best characterized of the DUB family. There are 63 putative human USP genes, and the proteins they encode are normally between 60 and 300 kDa in size. USPs cleave the isopeptide bond at the C-terminus of ubiquitin, preventing ...