IN 1130

Catalog # Availability Size / Price Qty
IN 1130 | CAS No. 868612-83-3 | TGF-beta Receptor Inhibitors
1 Image
Description: Potent and selective inhibitor of TGF-βRI

Chemical Name: 3-[[5-(6-Methyl-2-pyridinyl)-4-(6-quinoxalinyl)-1H-imidazol-2-yl]methyl]benzamide

Purity: ≥98%

Product Details
Supplemental Products

Biological Activity

IN 1130 is a potent and selective inhibitor of TGF-β type I receptor (ALK5). Inhibits Smad-2 phosphorylation (IC50 = 5.3 nM). Exhibits selectivity over a panel of 27 serine/ threonine and tyrosine kinases including P38α. Attenuates TGFβ/Smad signaling, cell migration, invasion, lung metastasis and increases survival of mice in 4TI in vivo models. Suppresses renal fibrosis in obstructive nephropathy in vivo models.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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