Indatraline hydrochloride

Key Product Details

Product Description

Indatraline hydrochloride is a potent monoamine uptake inhibitor. Inhibits transporters for 5-HT (SERT), dopamine (DAT) and noradrenaline (NET) (K_i values are 0.42, 1.7 and 5.8 nM respectively). Centrally active following systemic administration in vivo.

Product Specifications for Indatraline hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Indatraline hydrochloride

The following data is based on the product molecular weight 328.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.04 mL	15.21 mL	30.43 mL
5 mM	0.61 mL	3.04 mL	6.09 mL
10 mM	0.30 mL	1.52 mL	3.04 mL
50 mM	0.06 mL	0.30 mL	0.61 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Hyttel and Larsen Neurochemical profile of Lu 19-005, a potent inhibitor of uptake of DA, noradrenaline and serotonin. J.Neurochem. 1985 PMID: 2580950
• Negus Effects of the long-acting monoamine reuptake inhibitor indatraline on cocaine self-administration in rhesus monkeys. J.Pharmacol.Exp.Ther. 1999 PMID: 10490887
• Gu Design, synthesis, and monoamine transporter binding site affinities of methoxy derivatives of indatraline. J.Med.Chem. 2000 PMID: 11123996

Product Documents for Indatraline hydrochloride