Indian Hedgehog/Ihh Antibody (S03-3F2)

Novus Biologicals | Catalog # NBP3-19878

Recombinant Monoclonal Antibody
Novus Biologicals
100% Guarantee

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S03-3F2 expressed in HEK293
View all Indian Hedgehog/Ihh Primary Antibodies »

Product Specifications

Immunogen

A synthetic peptide of human Indian Hedgehog/Ihh (Uniprot # Q14623)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

45 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Indian Hedgehog/Ihh Antibody (S03-3F2)

Western Blot: Indian Hedgehog/Ihh Antibody (S03-3F2) [NBP3-19878]

Western Blot: Indian Hedgehog/Ihh Antibody (S03-3F2) [NBP3-19878]

Western Blot: Indian Hedgehog/Ihh Antibody (S03-3F2) [NBP3-19878] - Western blot detection of Indian Hedgehog/Ihh in HepG2, U2OS, HL-60, Lncap using NBP3-19878 (1:1000 diluted)

Applications for Indian Hedgehog/Ihh Antibody (S03-3F2)

Application
Recommended Usage

Western Blot

1/2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Indian Hedgehog/Ihh

Hedgehog, WNT, FGF and BMP signaling pathways network together during embryogenesis, tissue regeneration, and carcinogenesis. Aberrant activation of Hedgehog signaling pathway leads to pathological consequences in a variety of human tumors, such as gastric cancer and pancreatic cancer (1). The hedgehog family of morphogens are regulators of cell proliferation, differentiation and cell-cell communication. These morphogens have been shown to have important roles in organogenesis, spermatogenesis, stem cell maintenance and oncogenesis. Indian hedgehog (IHH) has been shown to be expressed in the uterine epithelium under the control of the steroid hormone, progesterone (2). It has been shown that IHH, synthesized by prehypertrophic and hypertrophic chondrocytes, regulates the site of hypertrophic differentiation by signaling to the periarticular growth plate and also determines the site of bone collar formation in the adjacent perichondrium. By providing crucial local signals from prehypertrophic and hypertrophic chondrocytes to both chondrocytes and preosteoblasts, IHH couples chondrogenesis to osteogenesis in endochondral bone development (3).

Alternate Names

BDA1, HHG2, Ihh

Gene Symbol

IHH

Additional Indian Hedgehog/Ihh Products

Product Documents for Indian Hedgehog/Ihh Antibody (S03-3F2)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for Indian Hedgehog/Ihh Antibody (S03-3F2)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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