Indinavir sulfate

Key Product Details

Product Description

Indinavir sulfate is a potent and selective HIV protease inhibitor (K_i values are 0.52 and 3.3 nM for HIV-1 and HIV-2, respectively). Indinavir stops the spread of the HIV-infected MT4 lymphoid cells at concentrations of 25-50 nM. Indinavir disrupts the ERK1/2 and p38 MAPK pathways and reduces both the level of functional eIF4F complex and rpS6 phosphorylation, which leads to a decrease in protein synthesis in mouse myocytes. In silico docking models predict potential as an inhibitor of SARS-CoV-2 3CL^pro.

Product Specifications for Indinavir sulfate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Indinavir sulfate

The following data is based on the product molecular weight 711.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.40 mL	7.02 mL	14.05 mL
5 mM	0.28 mL	1.40 mL	2.81 mL
10 mM	0.14 mL	0.70 mL	1.40 mL
50 mM	0.03 mL	0.14 mL	0.28 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Hall A search for medications to treat COVID-19 via in silico molecular docking models of the SARS-CoV-2 spike glycoprotein and 3CL protease. Travel Med.Infect.Dis. 2020 PMID: 32294562
• Brown Indinavir impairs protein synthesis and phosphorylations of MAPKs in mouse C₂C₁₂ myocytes. Am.J.Physiol.Cell Physiol. 2004 PMID: 15229102
• Brown Indinavir alters regulators of protein anabolism and catabolism in skeletal muscle. Am.J.Physiol.Endocrinol.Metab. 2005 PMID: 15827064
• Dorsey L-735,524: the design of a potent and orally bioavailable HIV protease inhibitor. J.Med.Chem. 1994 PMID: 7932573

Product Documents for Indinavir sulfate