Biological ActivityEndogenous insulin receptor agonist (Ki = 4.85 nM). Decreases plasma glucose levels, proteolysis, lipolysis and gluconeogenesis and increases glycogen and fatty acid synthesis in vivo.
(Modifications: Disulfide bridge between 6 - 11, 7 -7*, 20 - 19*)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Age dependent changes of Ins receptors in rat tissues.
Torlinska et al.
The binding characteristics of Ins-MTX to Ins receptor.
Ou et al.
The molecular basis of Ins-stimulated glucose uptake: signalling, trafficking and potential drug targets.
Leney and Tavare
Citations for Insulin (human) recombinant
expressed in yeast
The citations listed below are publications that use Tocris products.
Selected citations for Insulin (human) recombinant
expressed in yeast include:
3 Citations: Showing 1 - 3
ins. regulates POMC neuronal plasticity to control glucose metabolism.
Authors: Dodd Et al.
Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin.
Authors: Pinheiro Et al.
GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling.
Authors: Stretton Et al.
Br J Pharmacol 2015;470:207
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expressed in yeast
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