Catalog Number: 4464
Alternate Names: 5-carboxy-8HQ
Chemical Name: 8-Hydroxy-5-quinolinecarboxylic acid
Biological Activity
Histone demethylase JMJD inhibitor (IC50 values are 0.12, 0.17, 0.2, 0.3, 0.6 and 1 μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively). Cell permeable; inhibits JMJD2A-mediated H3K9me3 demethylation in HeLa cells.
Technical Data
  • M.Wt:
    189.17
  • Formula:
    C10H7NO3
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in 1eq. NaOH
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    5852-78-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the IOX 1 summary on the SGC website.
Background References
  1. Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.
    King et al.
    PLoS One., 2010;5:e15535

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