Catalog # Availability Size / Price Qty
IOX 1 | CAS No. 5852-78-8 | Histone Demethylase Inhibitors
1 Image
Description: Histone demethylase inhibitor; cell permeable
Alternative Names: 5-carboxy-8HQ

Chemical Name: 8-Hydroxy-5-quinolinecarboxylic acid

Purity: ≥99%

Product Details
Citations (3)

Biological Activity

IOX 1 is a histone demethylase JMJD inhibitor (IC50 values are 0.12, 0.17, 0.2, 0.3, 0.6 and 1 μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively). Cell permeable; it inhibits JMJD2A-mediated H3K9me3 demethylation in HeLa cells. IOX 1 suppresses IL-17 expression in mouse and human CD4+ T cells by targeting TET2. It also reduces infiltration of Th17 cells in an in vivo model of intraocular inflammation.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in 1eq. NaOH
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the IOX 1 summary on the SGC website.

Product Datasheets

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Citations for IOX 1

The citations listed below are publications that use Tocris products. Selected citations for IOX 1 include:

3 Citations: Showing 1 - 3


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