IOX 1

Catalog # Availability Size / Price Qty
4464/10
4464/50
Cat.No. 4464 - IOX 1 | C10H7NO3 | CAS No. 5852-78-8
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Description: Histone demethylase inhibitor; cell permeable
Alternative Names: 5-carboxy-8HQ

Chemical Name: 8-Hydroxy-5-quinolinecarboxylic acid

Product Details
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Biological Activity

Histone demethylase JMJD inhibitor (IC50 values are 0.12, 0.17, 0.2, 0.3, 0.6 and 1 μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively). Cell permeable; inhibits JMJD2A-mediated H3K9me3 demethylation in HeLa cells.

Technical Data

Formula:
C10H7NO3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in 1eq. NaOH
Storage:
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
CAS No:
5852-78-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Licensing Caveats:
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the IOX 1 summary on the SGC website.

Product Datasheets

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