Chemical Name: 8-Hydroxy-5-quinolinecarboxylic acid
Biological ActivityHistone demethylase JMJD inhibitor (IC50 values are 0.12, 0.17, 0.2, 0.3, 0.6 and 1 μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively). Cell permeable; inhibits JMJD2A-mediated H3K9me3 demethylation in HeLa cells.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.
King et al.
PLoS One., 2010;5:e15535
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