Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells; enables Wnt/β
-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation. Upregulates expression of Oct4
transcription factors. Binds to serine/threonine phosphatase PP2A and prevents PP2A/Nkd interaction.
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Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency.
Miyabayashi T, Teo JL, Yamamoto M et al.
Proc Natl Acad Sci U S A.
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