Chemical Name: 2-[2-(4-Acetylphenyl)diazenyl]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)acetamide
Biological ActivityMaintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells; enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation. Upregulates expression of Oct4 and Sox2 transcription factors. Binds to serine/threonine phosphatase PP2A and prevents PP2A/Nkd interaction.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency.
Miyabayashi T, Teo JL, Yamamoto M, McMillan M, Nguyen C, Kahn M
Proc. Natl. Acad. Sci. U.S.A., 2007;104(13):5668-73.
Citations for IQ 1
The citations listed below are publications that use Tocris products. Selected citations for IQ 1 include:
2 Citations: Showing 1 - 2
β-Catenin Directs Nuclear Factor-κB p65 Output via CREB-Binding Protein/p300 in Human Airway Smooth Muscle.
Authors: Koopmans Et al.
Front Immunol 2017;8:1086
Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin.
Authors: Long Et al.
J Neurosci 2016;7:10354
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