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IQ 1

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IQ 1 | CAS No. 331001-62-8 | Compounds for Induced Pluripotent Stem Cells
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Description: Enables Wnt/β-catenin-driven expansion of ESCs; prevents spontaneous differentiation

Chemical Name: 2-[2-(4-Acetylphenyl)diazenyl]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)acetamide

Purity: ≥99%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells; enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation. Upregulates expression of Oct4 and Sox2 transcription factors. Binds to serine/threonine phosphatase PP2A and prevents PP2A/Nkd interaction.

Technical Data

M.Wt:
362.42
Formula:
C21H22N4O2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
331001-62-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency.
    Miyabayashi T, Teo JL, Yamamoto M, McMillan M, Nguyen C, Kahn M
    Proc. Natl. Acad. Sci. U.S.A., 2007;104(13):5668-73.

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Citations for IQ 1

The citations listed below are publications that use Tocris products. Selected citations for IQ 1 include:

3 Citations: Showing 1 - 3

  1. β-Catenin Directs Nuclear Factor-κB p65 Output via CREB-Binding Protein/p300 in Human Airway Smooth Muscle.
    Authors: Koopmans Et al.
    Front Immunol  2017;8:1086
  2. Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin.
    Authors: Long Et al.
    J Neurosci  2016;7:10354
  3. Selective targeting of CREB-binding protein/β-catenin inhibits growth of and extracellular matrix remodelling by airway smooth muscle.
    Authors: Koopmans Et al.
    Br J Pharmacol  2016;173:3327

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