Chemical Name: 2-[2-(4-Acetylphenyl)diazenyl]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)acetamide
Biological ActivityMaintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells; enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation. Upregulates expression of Oct4 and Sox2 transcription factors. Binds to serine/threonine phosphatase PP2A and prevents PP2A/Nkd interaction.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency.
Miyabayashi T, Teo JL, Yamamoto M, McMillan M, Nguyen C, Kahn M
Proc. Natl. Acad. Sci. U.S.A., 2007;104(13):5668-73.
Citations for IQ 1
The citations listed below are publications that use Tocris products. Selected citations for IQ 1 include:
2 Citations: Showing 1 - 2
β-Catenin Directs Nuclear Factor-κB p65 Output via CREB-Binding Protein/p300 in Human Airway Smooth Muscle.
Authors: Koopmans Et al.
Front Immunol 2017;8:1086
Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin.
Authors: Long Et al.
J Neurosci 2016;7:10354
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