IQ 1 (CAS 331001-62-8): R&D Systems
Catalog Number: 4713
Chemical Name: 2-[2-(4-Acetylphenyl)diazenyl]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)acetamide
Biological Activity
Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells; enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation. Upregulates expression of Oct4 and Sox2 transcription factors. Binds to serine/threonine phosphatase PP2A and prevents PP2A/Nkd interaction.
Technical Data
  • M.Wt:
    362.42
  • Formula:
    C21H22N4O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    331001-62-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency.
    Miyabayashi T, Teo JL, Yamamoto M et al.
    Proc Natl Acad Sci U S A.
Citations:

The citations listed below are publications that use Tocris products. Selected citations for IQ 1 include:

1 Citations: Showing 1 - 1

  1. Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin.
    Authors: Long Et al.
    J Neurosci 2016;7:10354

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