Home / Compounds for Induced Pluripotent Stem Cells / IQ 1

IQ 1

4713 2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4713/10
4713/50
Cat.No. 4713 - IQ 1 | C21H22N4O2 | CAS No. 331001-62-8
1 Image
Description: Enables Wnt/β-catenin-driven expansion of ESCs; prevents spontaneous differentiation

Chemical Name: 2-[2-(4-Acetylphenyl)diazenyl]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)acetamide

Purity: ≥99%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells; enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation. Upregulates expression of Oct4 and Sox2 transcription factors. Binds to serine/threonine phosphatase PP2A and prevents PP2A/Nkd interaction.

Technical Data

M.Wt:
362.42
Formula:
C21H22N4O2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
331001-62-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency.
    Miyabayashi T, Teo JL, Yamamoto M, McMillan M, Nguyen C, Kahn M
    Proc. Natl. Acad. Sci. U.S.A., 2007;104(13):5668-73.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for IQ 1

The citations listed below are publications that use Tocris products. Selected citations for IQ 1 include:

2 Citations: Showing 1 - 2

  1. β-Catenin Directs Nuclear Factor-κB p65 Output via CREB-Binding Protein/p300 in Human Airway Smooth Muscle.
    Authors: Koopmans Et al.
    Front Immunol  2017;8:1086
  2. Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin.
    Authors: Long Et al.
    J Neurosci  2016;7:10354

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for IQ 1

There are currently no reviews for this product. Be the first to review IQ 1 and earn rewards!

Have you used IQ 1?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.