Ischemin sodium salt
Chemical Name: 5-[(1E)-2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-2,4-dimethylbenzenesulfonic acid sodium salt
Biological ActivityIschemin sodium salt is a CBP bromodomain inhibitor. Inhibits p53 interaction with CBP and decreases p53 transcriptional activity. Protects against Doxorubicin-induced apoptosis in cardiomyocytes in vitro. Cell permeable.
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A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes.
Borah et al.
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