Doxorubicin hydrochloride

  ( 16 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:2252
Alternate Names:Adriamycin, NSC 123127
Chemical Name:10-[(3-Amino-2,3,6-trideoxy-α-L-lyxohexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-5,12-naphthacenedione hydrochloride
Product Details
Citations (16)
Reviews
Biological Activity
Antitumor antibiotic agent that inhibits DNA topoisomerase II. DNA intercalator that inhibits nucleic acid synthesis and induces apoptosis. Reduces intracellular tau levels.
Technical Data
  • M.Wt:
    579.99
  • Formula:
    C27H29NO11.HCl
  • Solubility:
    Soluble to 50 mM in water and to 50 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at RT
  • CAS No:
    25316-40-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Doxorubicin hydrochloride include:

16 Citations: Showing 1 - 10
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  1. Tenovin-6 impairs autophagy by inhibiting autophagic flux.
    Authors: Yuan Et al.
    Cell Death Dis  2017;8:e2608
  2. The EphB6 receptor is overexpressed in pediatric T cell acute lymphoblastic leukemia and increases its sensitivity to doxorubicin treatment.
    Authors: El Zawily
    Sci Rep  2017;7(1):14767
  3. An Alpha-1A Adrenergic Receptor Agonist Prevents Acute Doxorubicin Cardiomyopathy in Male Mice.
    Authors: Montgomery
    Plos One  2017;12:e0168409
  4. Crizotinib, a MET inhibitor, inhibits growth, migration, and invasion of breast cancer cells in vitro and synergizes with chemotherapeutic agents.
    Authors: Ayoub
    Onco Targets Ther  2017;10:4869
  5. Targeting polo-like kinase 1, a regulator of p53, in the treatment of adrenocortical carcinoma.
    Authors: Bussey Et al.
    PLoS One  2016;5:1
  6. A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart.
    Authors: Thomas Et al.
    JACC Basic Transl Sci  2016;1:155
  7. Extracellular ATP protects endothelial cells against DNA damage.
    Authors: Aho Et al.
    Purinergic Signal  2016;12:575
  8. The α-1A Adrenergic Receptor in the Rabbit Heart.
    Authors: Thomas Et al.
    Mol Syst Biol  2016;11:e0155238
  9. Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance.
    Authors: Zhitomirsky and Assaraf
    Clin Transl Med  2015;6:1143
  10. Biodistribution and delivery efficiency of unmodified tumor-derived exosomes.
    Authors: Smyth Et al.
    J Control Release  2015;199:145
  11. Dual-responsive polymer-coated iron oxide nanoparticles for drug delivery and imaging applications.
    Authors: Sundaresan Et al.
    Int J Pharm  2014;466:1
  12. RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs.
    Authors: Robinson Et al.
    PLoS One  2013;8:e78641
  13. Comparative cardiac toxicity of anthracyclines in vitro and in vivo in the mouse.
    Authors: Toldo Et al.
    PLoS One  2013;8:e58421
  14. Development of a screen to identify selective small molecules active against patient-derived metastatic and chemoresistant breast cancer cells.
    Authors: Gligorich Et al.
    Breast Cancer Res  2013;15:R58
  15. Functional characterization of the 19q12 amplicon in grade III breast cancers.
    Authors: Natrajan Et al.
    Breast Cancer Res  2012;14:R53
  16. B cell translocation gene 2 enhances susceptibility of HeLa cells to doxorubicin-induced oxidative damage.
    Authors: Lim Et al.
    J Biol Chem  2008;283:33110
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Average Rating: 5 (Based on 1 review)

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 2uM Doxorubicin damaged NRVM cells in 12 hr  2252 Array 2252
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  Rat Anonymous 12/12/2017
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 2uM Doxorubicin damaged NRVM cells in 12 hr  2252
: 2uM Doxorubicin damaged NRVM cells in 12 hr [2252].

Summary

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Pub Med ID 28286875

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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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