Antitumor antibiotic agent that inhibits DNA topoisomerase II. DNA intercalator that inhibits nucleic acid synthesis and induces apoptosis. Reduces intracellular tau levels.
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Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumour cells.
Skladanowski and Konopa
Identification of yeast DNA topoisomerase II mutants resistant to the antitumor drug doxorubicin: implications for the mechanisms of doxorubicin action and cyotoxicity.
Patel et al.
A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin.
Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression.
Dickey et al.
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