Catalog Number: 2252
Alternate Names: Adriamycin, NSC 123127
Chemical Name: 10-[(3-Amino-2,3,6-trideoxy-α-L-lyxohexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-5,12-naphthacenedione hydrochloride
Biological Activity
Antitumor antibiotic agent that inhibits DNA topoisomerase II. DNA intercalator that inhibits nucleic acid synthesis and induces apoptosis. Reduces intracellular tau levels.
Technical Data
  • M.Wt:
    579.99
  • Formula:
    C27H29NO11.HCl
  • Solubility:
    Soluble to 50 mM in water and to 50 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    25316-40-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumour cells.
    Skladanowski and Konopa
    Biochem.Pharmacol., 1993;46:357
  2. Identification of yeast DNA topoisomerase II mutants resistant to the antitumor drug doxorubicin: implications for the mechanisms of doxorubicin action and cyotoxicity.
    Patel et al.
    Mol.Pharmacol., 1997;52:658
  3. A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin.
    Gewirtz
    Biochem.Pharmacol., 1999;57:727
  4. Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression.
    Dickey et al.
    Mol.Neurodegen., 2006;1:6
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Doxorubicin hydrochloride include:

10 Citations: Showing 1 - 10
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  1. An Alpha-1A Adrenergic Receptor Agonist Prevents Acute Doxorubicin Cardiomyopathy in Male Mice.
    Authors: Montgomery
    Plos One 2017;12:e0168409
  2. Crizotinib, a MET inhibitor, inhibits growth, migration, and invasion of breast cancer cells in vitro and synergizes with chemotherapeutic agents.
    Authors: Ayoub
    Onco Targets Ther 2017;10:4869
  3. Targeting polo-like kinase 1, a regulator of p53, in the treatment of adrenocortical carcinoma.
    Authors: Bussey Et al.
    PLoS One 2016;5:1
  4. The α-1A Adrenergic Receptor in the Rabbit Heart.
    Authors: Thomas Et al.
    Mol Syst Biol 2016;11:e0155238
  5. Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance.
    Authors: Zhitomirsky and Assaraf
    Clin Transl Med 2015;6:1143
  6. Biodistribution and delivery efficiency of unmodified tumor-derived exosomes.
    Authors: Smyth Et al.
    J Control Release 2015;199:145
  7. Dual-responsive polymer-coated iron oxide nanoparticles for drug delivery and imaging applications.
    Authors: Sundaresan Et al.
    Int J Pharm 2014;466:1
  8. RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs.
    Authors: Robinson Et al.
    PLoS One 2013;8:e78641
  9. Comparative cardiac toxicity of anthracyclines in vitro and in vivo in the mouse.
    Authors: Toldo Et al.
    PLoS One 2013;8:e58421
  10. Functional characterization of the 19q12 amplicon in grade III breast cancers.
    Authors: Natrajan Et al.
    Breast Cancer Res 2012;14:R53

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