Catalog Number: 2252
Alternate Names: Adriamycin, NSC 123127
Chemical Name: 10-[(3-Amino-2,3,6-trideoxy-α-L-lyxohexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-5,12-naphthacenedione hydrochloride
Biological Activity
Antitumor antibiotic agent that inhibits DNA topoisomerase II. DNA intercalator that inhibits nucleic acid synthesis and induces apoptosis. Reduces intracellular tau levels.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in water and to 50 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumour cells.
    Skladanowski and Konopa
    Biochem.Pharmacol., 1993;46:357
  2. Identification of yeast DNA topoisomerase II mutants resistant to the antitumor drug doxorubicin: implications for the mechanisms of doxorubicin action and cyotoxicity.
    Patel et al.
    Mol.Pharmacol., 1997;52:658
  3. A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin.
    Biochem.Pharmacol., 1999;57:727
  4. Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression.
    Dickey et al.
    Mol.Neurodegen., 2006;1:6
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