Chemical Name: 10-[(3-Amino-2,3,6-trideoxy-α-L-lyxohexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-5,12-naphthacenedione hydrochloride
Biological ActivityDoxorubicin hydrochloride is a 14-hydroxylated version of Daunorubicin (Cat. No. 1467) that is naturally fluorescent. Doxorubicin is an antitumor antibiotic agent that inhibits DNA topoisomerase II. It is a DNA intercalator that inhibits nucleic acid synthesis and induces apoptosis. Doxorubicin reduces intracellular tau levels. Doxorubicin also promotes formation of free radicals for the disruption of membrane lipids and DNA strands. Doxorubicin fluorescence is quenched upon intercalation into the DNA; while binding to histones or partitioning into the phospholipid phase of PEG-phospholipid micelles or hydrophobic cores of polymeric micelles, increases Doxorubicin fluorescence. Doxorubicin fluorescence enables the monitoring of the localization of the drug within lipid bilayers and liposomal delivery systems and interaction of the drug with DNA and other macromolecules, as well as drug efflux pump activities.
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Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumour cells.
Skladanowski and Konopa
Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression.
Dickey et al.
Identification of yeast DNA topoisomerase II mutants resistant to the antitumor drug doxorubicin: implications for the mechanisms of dox. action and cyotoxicity.
Patel et al.
A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunoru.
Citations for Doxorubicin hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Doxorubicin hydrochloride include:
28 Citations: Showing 1 - 10
Extracorporeal shock waves protect cardiomyocytes from DOX-induced cardiomyopathy by upregulating survivin via the integrin-ILK-Akt-Sp1/p53 axis.
Authors: Lee Et al.
Sci Rep 2019;9:12149
Drug-loaded exosomal preparations from different cell types exhibit distinctive loading capability, yield, and antitumor efficacies: a comparative analysis.
Authors: Kanchanapally Et al.
Int J Nanomedicine 2019;14:531
Regulation of senescence escape by TSP1 and CD47 following chemotherapy treatment.
Authors: Guillon Et al.
Cell Death Dis 2019;10:199
p53 induces senescence through Lamin A/C stabilization-mediated nuclear deformation.
Authors: Yoon Et al.
Cell Death Dis 2019;10:107
Regulation of senescence escape by the cdk4-EZH2-AP2M1 pathway in response to chemotherapy.
Authors: Duff Et al.
Cell Death Dis 2018;9:199
TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negativebreast cancer lung metastasis.
Nat Commun 2018;9(1):1994
Lysosomotropism depends on glucose: a chloroquine resistance mechanism.
Authors: Gallagher Et al.
Cell Death Dis 2017;8:e3014
Tenovin-6 impairs autophagy by inhibiting autophagic flux.
Authors: Yuan Et al.
Cell Death Dis 2017;8:e2608
The EphB6 receptor is overexpressed in pediatric T cell acute lymphoblastic leukemia and increases its sensitivity to dox. treatment.
Authors: El Zawily
Sci Rep 2017;7(1):14767
An Oral Selective Alpha-1A Adrenergic Receptor Agonist Prevents Drug-induced Cardiotoxicity.
Authors: Beak Et al.
JACC Basic Transl Sci 2017;2:39
Isolation and characterization of a new naturally immortalized human breast carcinoma cell line, KAIMRC1.
Authors: Ali Et al.
BMC Cancer 2017;17:803
An Alpha-1A Adrenergic Receptor Agonist Prevents Acute dox. Cardiomyopathy in Male Mice.
Plos One 2017;12:e0168409
Crizotinib, a MET inhibitor, inhibits growth, migration, and invasion of breast cancer cells in vitro and synergizes with chemotherapeutic agents.
Onco Targets Ther 2017;10:4869
AMB potentiates the anticancer activity of Drug-induced on the MCF-7 breast cancer cells.
Authors: Tavangar Et al.
J Chem Biol 2017;10:143
Targeting polo-like kinase 1, a regulator of p53, in the treatment of adrenocortical carcinoma.
Authors: Bussey Et al.
PLoS One 2016;5:1
Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation.
Authors: Hayano Et al.
Cell Death Differ 2016;23:270
A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart.
Authors: Thomas Et al.
JACC Basic Transl Sci 2016;1:155
Extracellular ATP protects endothelial cells against DNA damage.
Authors: Aho Et al.
Purinergic Signal 2016;12:575
The α-1A Adrenergic Receptor in the Rabbit Heart.
Authors: Thomas Et al.
Mol Syst Biol 2016;11:e0155238
Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance.
Authors: Zhitomirsky and Assaraf
Clin Transl Med 2015;6:1143
Biodistribution and delivery efficiency of unmodified tumor-derived exosomes.
Authors: Smyth Et al.
J Control Release 2015;199:145
Dual-responsive polymer-coated iron oxide nanoparticles for drug delivery and imaging applications.
Authors: Sundaresan Et al.
Int J Pharm 2014;466:1
RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs.
Authors: Robinson Et al.
PLoS One 2013;8:e78641
Attenuation of doxorubicin-induced cardiotoxicity by mdivi-1: a mitochondrial division/mitophagy inhibitor.
Authors: Gharanei Et al.
PLoS One 2013;8:e77713
Comparative cardiac toxicity of anthracyclines in vitro and in vivo in the mouse.
Authors: Toldo Et al.
PLoS One 2013;8:e58421
Development of a screen to identify selective small molecules active against patient-derived metastatic and chemoresistant breast cancer cells.
Authors: Gligorich Et al.
Breast Cancer Res 2013;15:R58
Functional characterization of the 19q12 amplicon in grade III breast cancers.
Authors: Natrajan Et al.
Breast Cancer Res 2012;14:R53
B cell translocation gene 2 enhances susceptibility of HeLa cells to doxorubicin-induced oxidative damage.
Authors: Lim Et al.
J Biol Chem 2008;283:33110
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