hh Ispinesib (CAS 336113-53-2): R&D Systems
Catalog Number: 5408
Alternate Names: SB 715992
Chemical Name: N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]-2-methylpropyl]-4-methylbenzamide
Biological Activity
High affinity allosteric kinesin spindle protein (KSP) inhibitor (Ki app = 1.7 nM). Exhibits >10,000-fold selectivity for KSP over a range of other mitotic kinesins. Inhibits proliferation and induces apoptosis of prostate and breast cancer cells in vitro. Induces tumor regression of breast cancer cell xenografts in mice.
Technical Data
  • M.Wt:
    517.06
  • Formula:
    C30H33ClN4O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    336113-53-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Mechanism of inhibition of human KSP by ispinesib.
    Lad et al.
    Biochemistry, 2008;47:3576
  2. Increased therapeutic potential of an experimental anti-mitotic inhibitor SB715992 by genistein in PC-3 human prostate cancer cell line.
    Davis et al.
    BMC Cancer, 2006;6:22
  3. Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer.
    Purcell et al.
    Clin.Cancer Res., 2010;16:566

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