High affinity allosteric kinesin spindle protein (KSP) inhibitor (Ki app
= 1.7 nM). Exhibits >10,000-fold selectivity for KSP over a range of other mitotic kinesins. Inhibits proliferation and induces apoptosis of prostate and breast cancer cells in vitro
. Induces tumor regression of breast cancer cell xenografts in mice.
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All Tocris products are intended for laboratory research use only.
Mechanism of inhibition of human KSP by ispinesib.
Lad et al.
Increased therapeutic potential of an experimental anti-mitotic inhibitor SB715992 by genistein in PC-3 human prostate cancer cell line.
Davis et al.
BMC Cancer, 2006;6:22
Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer.
Purcell et al.
Clin.Cancer Res., 2010;16:566