IT1t dihydrochloride
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Description: Potent CXCR4 antagonist
Chemical Name: N,N'-Dicyclohexylcarbamimidothioic acid (5,6-dihydro-6,6-dimethylimidazo[2,1-b]thiazol-3-yl)methyl ester dihydrochloride
Biological Activity
Potent CXCR4 antagonist (IC50 = 1.1 nM in calcium mobilization assays). Orally available. Blocks interaction with the HIV envelope protein, gp120 (IC50 = 7 nM, inhibition of X4-tropic HIV-1IIIB attachment).Technical Data
Formula:
C21H34N4S2.2HCl
Solubility:
Soluble to 10 mM in DMSO and to 100 mM in water
Storage:
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
CAS No:
1092776-63-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
-
Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivo.
Thoma et al.
J.Med.Chem., 2008;51:7915
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