IT1t dihydrochloride
1 Image
Description: Potent CXCR4 antagonist
Chemical Name: N,N'-Dicyclohexylcarbamimidothioic acid (5,6-dihydro-6,6-dimethylimidazo[2,1-b]thiazol-3-yl)methyl ester dihydrochloride
Purity: ≥99%
Biological Activity
Potent CXCR4 antagonist (IC50 = 1.1 nM in calcium mobilization assays). Orally available. Blocks interaction with the HIV envelope protein, gp120 (IC50 = 7 nM, inhibition of X4-tropic HIV-1IIIB attachment).Technical Data
M.Wt:
479.57
Formula:
C21H34N4S2.2HCl
Solubility:
Soluble to 10 mM in DMSO and to 100 mM in water
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
1092776-63-0
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivo.
Thoma et al.
J.Med.Chem., 2008;51:7915
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Reconstitution Calculator
Molarity Calculator
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsVersaClone cDNA Plasmids
Reviews for IT1t dihydrochloride
There are currently no reviews for this product. Be the first to review IT1t dihydrochloride and earn rewards!
Have you used IT1t dihydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris Bioscience is the leading supplier of novel and exclusive
tools for
life science research with over 30 years' experience in the
industry.
Tocris is a Bio-Techne brand.
