IT1t dihydrochloride

Key Product Details

Product Description

IT1t dihydrochloride is a potent CXCR4 antagonist (IC₅₀ = 1.1 nM in calcium mobilization assays). Orally available. Blocks interaction with the HIV envelope protein, gp120 (IC₅₀ = 7 nM, inhibition of X4-tropic HIV-1IIIB attachment).

Product Specifications for IT1t dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for IT1t dihydrochloride

The following data is based on the product molecular weight 479.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.09 mL	10.43 mL	20.85 mL
5 mM	0.42 mL	2.09 mL	4.17 mL
10 mM	0.21 mL	1.04 mL	2.09 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

• Thoma Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivo. J.Med.Chem. 2008 PMID: 19053768

Product Documents for IT1t dihydrochloride