IT1t dihydrochloride

Catalog # Availability Size / Price Qty
4596/10
4596/50
Chemokine Receptor Antagonists Small Molecule
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Description: Potent CXCR4 antagonist

Chemical Name: N,N'-Dicyclohexylcarbamimidothioic acid (5,6-dihydro-6,6-dimethylimidazo[2,1-b]thiazol-3-yl)methyl ester dihydrochloride

Purity: ≥99%

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Biological Activity

Potent CXCR4 antagonist (IC50 = 1.1 nM in calcium mobilization assays). Orally available. Blocks interaction with the HIV envelope protein, gp120 (IC50 = 7 nM, inhibition of X4-tropic HIV-1IIIB attachment).

Technical Data

M.Wt:
479.57
Formula:
C21H34N4S2.2HCl
Solubility:
Soluble to 10 mM in DMSO and to 100 mM in water
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
1092776-63-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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