J 104129 fumarate

Key Product Details

Product Description

J 104129 fumarate is a potent M₃ muscarinic receptor antagonist that displays ~ 120-fold selectivity over M₂ receptors (K_i values are 4.2, 19 and 490 nM for human M₃, M₁ and M₂ receptors respectively). Exhibits > 250-fold bronchial selectivity; inhibits ACh-induced bronchoconstriction but not ACh-induced bradycardia (K_B values are 3.3 and 170 nM for rat trachea M₃ and rat right atria M₂ receptors respectively).

Product Specifications for J 104129 fumarate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for J 104129 fumarate

The following data is based on the product molecular weight 500.63.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.00 mL	9.99 mL	19.97 mL
5 mM	0.40 mL	2.00 mL	3.99 mL
10 mM	0.20 mL	1.00 mL	2.00 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Mitsuya Discovery of a muscarinic M₃ receptor antagonist with high selectivity for M₃ over M₂ receptors among 2-[(1S,3S)-3-sulfonylaminocyclopentyl]phenylacetamide derivatives. Bioorg.Med.Chem. 2000 PMID: 10819171
• Mitsuya Stereoselective synthesis of a new muscarinic M₃ receptor antagonist, J-104129. Bioorrg.Med.Chem.Lett.
• Mitsuya J-104129, a novel muscarinic M₃ receptor antagonist with high selectivity for M₃ over M₂ receptors. Bioorg.Med.Chem. 1999 PMID: 10632066

Product Documents for J 104129 fumarate