Catalog Number: 5081
Chemical Name: 2,2,2-Trifluoroacetic acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide
Biological Activity
Potent neuroprotective and neurotrophic compound. Protects against neurotoxicity in cortical neurons in vitro (EC50 = 25 - 200 nM). Reduces soluble Aβ40 and Aβ42 levels and increases BDNF levels in the hippocampus in vivo. Enhances memory in wild type rats. Prevents memory deficits and rescues cognitive deficits in young and aged transgenic Alzheimer's disease mice, respectively. Orally active.
Technical Data
  • M.Wt:
    350.33
  • Formula:
    C18H17F3N2O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    1146963-51-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research use only under license from the Salk Institute for Biological Studies
Background References
  1. The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice.
    Prior M, Dargusch R, Ehren JL et al.
    Alzheimers Res Ther
  2. Metabolism of a potent neuroprotective hydrazide.
    Chiruta et al.
    Bioorg.Med.Chem., 2013;21:2733
  3. A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease.
    Chen et al.
    PLoS One, 2011;6:e27865

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