Potent neuroprotective and neurotrophic compound. Protects against neurotoxicity in cortical neurons in vitro
= 25 - 200 nM). Reduces soluble Aβ
40 and Aβ
42 levels and increases BDNF levels in the hippocampus in vivo
. Enhances memory in wild type rats. Prevents memory deficits and rescues cognitive deficits in young and aged transgenic Alzheimer's disease mice, respectively. Orally active.
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Sold for research use only under license from the Salk Institute for Biological Studies
The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice.
Prior M, Dargusch R, Ehren JL et al.
Alzheimers Res Ther
Metabolism of a potent neuroprotective hydrazide.
Chiruta et al.
A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease.
Chen et al.
PLoS One, 2011;6:e27865