J 147

Catalog # Availability Size / Price Qty
5081/10
5081/50
Cat.No. 5081 - J 147 | C18H17F3N2O2 | CAS No. 1146963-51-0
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Description: Neuroprotective and neurotrophic compound; reduces Aβ40 and Aβ42 levels

Chemical Name: 2,2,2-Trifluoroacetic acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide

Purity: ≥99%

Product Details
Reviews

Biological Activity

Potent neuroprotective and neurotrophic compound. Protects against neurotoxicity in cortical neurons in vitro (EC50 = 25 - 200 nM). Reduces soluble Aβ40 and Aβ42 levels and increases BDNF levels in the hippocampus in vivo. Enhances memory in wild type rats. Prevents memory deficits and rescues cognitive deficits in young and aged transgenic Alzheimer's disease mice, respectively. Orally active.

Technical Data

M.Wt:
350.33
Formula:
C18H17F3N2O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
1146963-51-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Licensing Caveats:
Sold for research use only under license from the Salk Institute for Biological Studies

Background References

  1. The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice.
    Prior M, Dargusch R, Ehren JL et al.
    Alzheimers Res Ther
  2. A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease.
    Chen et al.
    PLoS One, 2011;6:e27865
  3. Metabolism of a potent neuroprotective hydrazide.
    Chiruta et al.
    Bioorg.Med.Chem., 2013;21:2733

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