Chemical Name: 2,2,2-Trifluoroacetic acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide
Biological ActivityJ 147 is a potent neuroprotective and neurotrophic compound. Protects against neurotoxicity in cortical neurons in vitro (EC50 = 25 - 200 nM). Reduces soluble Aβ40 and Aβ42 levels and increases BDNF levels in the hippocampus in vivo. Enhances memory in wild type rats. Prevents memory deficits and rescues cognitive deficits in young and aged transgenic Alzheimer's disease mice, respectively. Orally active.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease.
Chen et al.
PLoS One, 2011;6:e27865
The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice.
Prior et al.
Metabolism of a potent neuroprotective hydrazide.
Chiruta et al.
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