JHW 007 hydrochloride

Key Product Details

Product Description

JHW 007 hydrochloride is a dopamine uptake inhibitor; displays high affinity for the dopamine transporter (DAT) (K_i = 25 nM compared to 1330 and 1730 for NET and SERT respectively). Suppresses the effects of cocaine administration in a dose-dependent manner and decreases cocaine and methamphetamine self-administration in rats.

Product Specifications for JHW 007 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for JHW 007 hydrochloride

The following data is based on the product molecular weight 421.95.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.37 mL	11.85 mL	23.70 mL
5 mM	0.47 mL	2.37 mL	4.74 mL
10 mM	0.24 mL	1.18 mL	2.37 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Hiranita Preclinical efficacy of N-substituted benztr. analogs as antagonists of metha. self-administration in rats. J.Pharmacol.Exp.Ther. 2014 PMID: 24194527
• Kopajtic DA transporter-dependent and -independent striatal binding of the benztr. analog JHW 007, a cocaine antagonist with low abuse liability. J.Pharmacol.Exp.Ther. 2010 PMID: 20855444
• Velaquez-Sanchez The high affinity DA uptake inhibitor, JHW 007, blocks cocaine-induced reward, locomotor stimulation and sensitization. Eur.Neuropsychopharmacol. 2010 PMID: 20413276
• Kristensen SLC6 neurotransmitter transporters: structure, function, and regulation. Pharmacol.Rev. 2011 PMID: 21752877

Product Documents for JHW 007 hydrochloride