JHW 007 hydrochloride

Catalog # Availability Size / Price Qty
4351/10
4351/50
JHW 007 hydrochloride | CAS No. 202645-74-7 | Dopamine Transporter Inhibitors
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Description: High affinity dopamine uptake inhibitor

Chemical Name: (3-endo)-3-[Bis(4-fluorophenyl)methoxy]-8-butyl-8-azabicyclo[3.2.1]octane hydrochloride

Purity: ≥99%

Product Details
Citations (1)
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Reviews

Biological Activity

Dopamine uptake inhibitor; displays high affinity for the dopamine transporter (DAT) (Ki = 25 nM compared to 1330 and 1730 for NET and SERT respectively). Suppresses the effects of cocaine administration in a dose-dependent manner and decreases cocaine and methamphetamine self-administration in rats.

Technical Data

M.Wt:
421.95
Formula:
C24H29F2NO.HCl
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
202645-74-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. SLC6 neurotransmitter transporters: structure, function, and regulation.
    Kristensen et al.
    Pharm.Rev., 2011;63:585
  2. The high affinity DA uptake inhibitor, JHW 007, blocks cocaine-induced reward, locomotor stimulation and sensitization.
    Velaquez-Sanchez et al.
    Eur.Neuropsychopharmacol., 2010;20:501
  3. DA transporter-dependent and -independent striatal binding of the benztr. analog JHW 007, a cocaine antagonist with low abuse liability.
    Kopajtic et al.
    J.Pharmacol.Exp.Ther., 2010;335:703
  4. Preclinical efficacy of N-substituted benztr. analogs as antagonists of metha. self-administration in rats.
    Hiranita et al.
    J.Pharmacol.Exp.Ther., 2014;348:174

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Citation for JHW 007 hydrochloride

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