Catalog Number: 4351
Chemical Name: (3-endo)-3-[Bis(4-fluorophenyl)methoxy]-8-butyl-8-azabicyclo[3.2.1]octane hydrochloride
Biological Activity
Dopamine uptake inhibitor; displays high affinity for the dopamine transporter (DAT) (Ki = 25 nM compared to 1330 and 1730 for NET and SERT respectively). Suppresses the effects of cocaine administration in a dose-dependent manner and decreases cocaine and methamphetamine self-administration in rats.
Technical Data
  • M.Wt:
    421.95
  • Formula:
    C24H29F2NO.HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    202645-74-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Dopamine transporter-dependent and -independent striatal binding of the benztropine analog JHW 007, a cocaine antagonist with low abuse liability.
    Kopajtic et al.
    J.Pharmacol.Exp.Ther., 2010;335:703
  2. The high affinity dopamine uptake inhibitor, JHW 007, blocks cocaine-induced reward, locomotor stimulation and sensitization.
    Velaquez-Sanchez et al.
    Eur.Neuropsychopharmacol., 2010;20:501
  3. SLC6 neurotransmitter transporters: structure, function, and regulation.
    Kristensen et al.
    Pharm.Rev., 2011;63:585
  4. Preclinical efficacy of N-substituted benztropine analogs as antagonists of methamphetamine self-administration in rats.
    Hiranita et al.
    J.Pharmacol.Exp.Ther., 2014;348:174
Citations:

The citations listed below are publications that use Tocris products. Selected citations for JHW 007 hydrochloride include:

1 Citations: Showing 1 - 1

  1. Binding site residues control inhibitor selectivity in the human norepinephrine transporter but not in the human dopamine transporter.
    Authors: Andersen Et al.
    Stem Cell Reports 2015;5:15650

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