Selective blocker of NaV
1.5 channels (IC50
= 348 nM); displays no effect on other isoforms, including NaV
1.6 and NaV
1.7. Thought to inhibit sodium channel activation by binding to the NaV
1.5 S3-S4 linker of domain II. Selectively inhibits the activation of cardiac sodium channels, but has no effect on sodium channels in dorsal root ganglion neurons.
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All Tocris products are intended for laboratory research use only.
Jingzhaotoxin-III, a novel spider toxin inhibiting activation of sodium channel in rat cardiac myocytes.
Xiao et al.
Molecular basis of the tarantula toxin jingzhaotoxin-III (β-TRTX-Cj1α) interacting with voltage sensors in sodium channel subtype Nav1.5.
Rong et al.
FASEB J., 2011;25:3177