JMV 449

Name: JMV 449
Brand: Tocris Bioscience
SKU: 1998
Price: 156 USD
Availability: InStock

Tocris Bioscience | Catalog # 1998

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Citations (243)

Product Documents

Potent neurotensin receptor agonist

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent neurotensin receptor agonist

View all Neurotensin Receptor Agonists »

Product Description

JMV 449 is a potent, metabolically stable neurotensin receptor agonist peptide (IC₅₀ = 0.15 nM for inhibition of [¹²⁵I]-NT binding to neonatal mouse brain; EC₅₀ = 1.9 nM for contraction of guinea pig ileum). Produces long-lasting hypothermic, neuroprotective and analgesic effects in mice following central administration in vivo.

Product Specifications for JMV 449

Molecular Weight

746.96

Formula

C₃₈H₆₆N₈O₇

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

139026-66-7

PubChem ID

164415

InChI Key

TZCYVPLNMOJUIL-GULBXNHPSA-N

SMILES

[H]N[C@@H](CCCCN)CN[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 0.8mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 243 publications citing the usage of this product.

Dubuc JMV 449: a pseudopeptide analogue of neurotensin-(8-13) with highly potent and long-lasting hypothermic and analgesic effects in the mouse. Eur.J.Pharmacol. 1992 PMID: 1425958
Torup Neuroprotective effect of the neurotensin analogue JMV-449 in a mouse model of permanent middle cerebral ischaemia. Neurosci.Lett. 2003 PMID: 14623134
Lugrin Reduced peptide bond pseudopeptide analogues of neurotensin: binding and biological activities, and in vitro metabolic stability. Eur.J.Pharmacol. 1991 PMID: 1812009

Product Documents for JMV 449

Certificate of Analysis

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Product Specific Notices for JMV 449

For research use only

Citations for JMV 449

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