Potent, metabolically stable neurotensin receptor agonist peptide (IC50
= 0.15 nM for inhibition of [125
I]-NT binding to neonatal mouse brain; EC50
= 1.9 nM for contraction of guinea pig ileum). Produces long-lasting hypothermic, neuroprotective and analgesic effects in mice following central administration in vivo
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Reduced peptide bond pseudopeptide analogues of neurotensin: binding and biological activities, and in vitro metabolic stability.
Lugrin et al.
JMV 449: a pseudopeptide analogue of neurotensin-(8-13) with highly potent and long-lasting hypothermic and analgesic effects in the mouse.
Dubuc et al.
Neuroprotective effect of the neurotensin analogue JMV-449 in a mouse model of permanent middle cerebral ischaemia.
Torup et al.