JNJ 10191584 maleate

  ( 3 citations )    
Product Datasheet
Catalog Number:2441
Alternate Names:VUF 6002
Chemical Name:1-[(5-Chloro-1H-benzimidazol-2-yl)carbonyl]-4-methylpiperazine maleate
Product Details
Citations (3)
Supplemental Products
Reviews
Biological Activity
Highly selective histamine H4 receptor silent antagonist; binds with high affinity to the human H4 receptor (Ki = 26 nM). > 540-fold selective over the H3 receptor (Ki = 14.1 μM). Inhibits mast cell and eosinophil chemotaxis in vitro with IC50 values of 138 and 530 nM respectively. Orally active in vivo.
Technical Data
  • M.Wt:
    394.81
  • Formula:
    C13H15ClN4O.C4H4O4
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at RT
  • CAS No:
    869497-75-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for JNJ 10191584 maleate include:

3 Citations: Showing 1 - 3
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  1. Histamine H3 receptor antagonist OUP-186 attenuates the proliferation of cultured human breast cancer cell lines
    Authors: Tanaka Et al.
    Biochemical and Biophysical Research Communication  2016;480:479
  2. Histamine H4 receptor antagonists as potent modulators of mammalian vestibular primary neuron excitability.
    Authors: Desmadryl Et al.
    Br J Pharmacol  2012;167:905
  3. The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS.
    Authors: Connelly Et al.
    Br J Pharmacol  2009;157:55

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