JNJ 10191584 maleate

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2441/10
2441/50
JNJ 10191584 maleate | CAS No. 869497-75-6 | Histamine H4 Receptor Antagonists
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Description: Selective H4 antagonist; orally active
Alternative Names: VUF 6002

Chemical Name: 1-[(5-Chloro-1H-benzimidazol-2-yl)carbonyl]-4-methylpiperazine maleate

Purity: ≥99%

Product Details
Citations (3)
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Biological Activity

Highly selective histamine H4 receptor silent antagonist; binds with high affinity to the human H4 receptor (Ki = 26 nM). > 540-fold selective over the H3 receptor (Ki = 14.1 μM). Inhibits mast cell and eosinophil chemotaxis in vitro with IC50 values of 138 and 530 nM respectively. Orally active in vivo.

Technical Data

M.Wt:
394.81
Formula:
C13H15ClN4O.C4H4O4
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
869497-75-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for JNJ 10191584 maleate

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