Highly selective histamine H4
receptor silent antagonist; binds with high affinity to the human H4
= 26 nM). > 540-fold selective over the H3
= 14.1 μ
M). Inhibits mast cell and eosinophil chemotaxis in vitro
values of 138 and 530 nM respectively. Orally active in vivo
Soluble to 50 mM in DMSO
Desiccate at RT
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Inhibitory effects of histamine H4 receptor antagonists on experimental colitis in the rat.
Varga et al.
Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H4 receptor antagonists.
Terzioglu et al.
Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine H4 antagonists.
Venable et al.