JNJ 10191584 maleate

Key Product Details

Product Description

JNJ 10191584 maleate is a highly selective histamine H₄ receptor silent antagonist; binds with high affinity to the human H₄ receptor (K_i = 26 nM). > 540-fold selective over the H₃ receptor (K_i = 14.1 μM). Inhibits mast cell and eosinophil chemotaxis in vitro with IC₅₀ values of 138 and 530 nM respectively. Orally active in vivo.

Product Specifications for JNJ 10191584 maleate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for JNJ 10191584 maleate

The following data is based on the product molecular weight 394.81.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.07 mL	25.33 mL	50.66 mL
2.5 mM	1.01 mL	5.07 mL	10.13 mL
5 mM	0.51 mL	2.53 mL	5.07 mL
25 mM	0.10 mL	0.51 mL	1.01 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Venable Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine H₄ antagonists. J.Med.Chem. 2005 PMID: 16366610
• Varga Inhibitory effects of histamine H₄ receptor antagonists on experimental colitis in the rat. Eur.J.Pharmacol. 2005 PMID: 16213481
• Terzioglu Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H₄ receptor antagonists. Bioorg.Med.Chem.Lett. 2004 PMID: 15454206

Product Documents for JNJ 10191584 maleate