JNJ 16259685

  ( 10 citations )    
Product Datasheet
Catalog Number:2333
Chemical Name:(3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone
Product Details
Citations (10)
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Reviews
Biological Activity
Sub-nanomolar potent, non-competitive mGlu1 antagonist (Ki = 0.34 nM). Inhibits glutamate-induced Ca2+ response at the human mGlu1 receptor with an IC50 value of 0.55 nM. Selective over mGlu5 (> 400-fold) and displays no activity at mGlu2, mGlu3, mGlu4, mGlu6, AMPA or NMDA receptors (IC50 > 10 μM). Centrally active following systemic administration.
Technical Data
  • M.Wt:
    325.41
  • Formula:
    C20H23NO3
  • Solubility:
    Soluble to 100 mM in ethanol and to 25 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    409345-29-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for JNJ 16259685 include:

10 Citations: Showing 1 - 10
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  1. Long-Term Potentiation at the Mossy Fiber-Granule Cell Relay Invokes Postsynaptic Second-Messenger Regulation of Kv4 Channels.
    Authors: Rizwan Et al.
    J Neurosci  2016;36:11196
  2. Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus.
    Authors: Tabatadze Et al.
    J Neurosci  2015;35:11252
  3. Activation of a temporal memory in purkinje cells by the mGluR7 receptor.
    Authors: Johansson Et al.
    Cell Rep.  2015;13:1741
  4. mGluR1 within the nucleus accumbens regulates alcohol intake in mice under limited-access conditions.
    Authors: Lum Et al.
    Neuropharmacology  2014;79:679
  5. Synaptic depression via mGluR1 positive allosteric modulation suppresses cue-induced cocaine craving.
    Authors: Loweth Et al.
    Nat Neurosci  2014;17:73
  6. Effects of a metabotropic glutamate 1 receptor antagonist on light responses of retinal ganglion cells in a rat model of retinitis pigmentosa.
    Authors: Jensen
    PLoS One  2013;8:e79126
  7. Prolonged postinhibitory rebound firing in the cerebellar nuclei mediated by group I metabotropic glutamate receptor potentiation of L-type calcium currents.
    Authors: Zheng and Raman
    J Neurosci  2011;31:10283
  8. Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines.
    Authors: Hildebrand Et al.
    J Neurosci  2009;29:9668
  9. Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells.
    Authors: Shin Et al.
    Aquat Toxicol  2008;105:746
  10. Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices.
    Authors: Fukunaga Et al.
    Br J Pharmacol  2007;151:870

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VersaClone cDNA Plasmids
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Human mGluR1 (AAB05337) VersaClone cDNA

RDC0983
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