JNJ 5207787

Key Product Details

Product Description

JNJ 5207787 is a selective NPY Y₂ antagonist (IC₅₀ = 0.1 μM). Displays 100-fold selectivity over NPY Y₁, Y₄ and Y₅ receptors; also displays selectivity against a panel of 50 receptors, ion channels and transporters. Brain penetrant.

Licensing Information

Sold with the permission of Janssen Pharmaceutica N.V.

Product Specifications for JNJ 5207787

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for JNJ 5207787

The following data is based on the product molecular weight 510.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.58 mL	97.91 mL	195.82 mL
0.5 mM	3.92 mL	19.58 mL	39.16 mL
1 mM	1.96 mL	9.79 mL	19.58 mL
5 mM	0.39 mL	1.96 mL	3.92 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Jablonowski Novel non-peptide neuropeptide Y Y₂ receptor antagonists. Bioorg.Med.Chem.Lett. 2004 PMID: 14980673
• Bonaventure Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a small molecule antagonist of the neuropeptide Y Y₂ receptor. J.Pharmacol.Exp.Ther. 2004 PMID: 14617685

Product Documents for JNJ 5207787