Catalog Number: 4018
Chemical Name: (2E)-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)-4-piperidinyl]-2-propenamide
Biological Activity
Selective NPY Y2 antagonist (IC50 = 0.1 μM). Displays 100-fold selectivity over NPY Y1, Y4 and Y5 receptors; also displays selectivity against a panel of 50 receptors, ion channels and transporters. Brain penetrant.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in DMSO with gentle warming and to 10 mM in ethanol with gentle warming
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Janssen Pharmaceutica N.V.
Background References
  1. Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a small molecule antagonist of the neuropeptide Y Y2 receptor.
    Bonaventure et al.
    J.Pharmacol.Exp.Ther., 2004;308:1130
  2. Novel non-peptide neuropeptide Y Y2 receptor antagonists.
    Jablonowski et al.
    Bioorg.Med.Chem.Lett., 2004;14:1239
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