JNJ 55511118

Key Product Details

Product Description

JNJ 55511118 is a high affinity and selective negative modulator of AMPA receptors containing TARP-γ8 (K_i = 26 nM). Exhibits <50% binding against a panel of 52 receptors, ion channels and transporters (except 5HT_2B and melatonin receptors 78% and 57%, respectively). Also displays minimal activity against other TARP-less AMPARs and AMPARs coexpressed with other TARPs or CNIH2. It reduces alcohol self-administration in a mouse models of chronic drinking. Orally bioavailable and brain penetrant. Anticonvulsant.

Licensing Information

Sold with the permission of Janssen Pharmaceutica N.V.

Product Specifications for JNJ 55511118

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for JNJ 55511118

The following data is based on the product molecular weight 328.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.04 mL	15.21 mL	30.43 mL
5 mM	0.61 mL	3.04 mL	6.09 mL
10 mM	0.30 mL	1.52 mL	3.04 mL
50 mM	0.06 mL	0.30 mL	0.61 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

• Witkin A Comment on "Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8". J.Pharmacol.Exp.Ther. 2016 PMID: 27528544
• Hoffman Inhibition of AMPA receptors (AMPARs) containing transmembrane AMPAR regulatory protein γ-8 with JNJ-55511118 shows preclinical efficacy in reducing chronic repetitive alcohol self-administration. Alcohol Clin.Exp.Res. 2021 PMID: 34086361
• Maher Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8. J.Pharmacol.Exp.Ther. 2016 PMID: 26989142

Product Documents for JNJ 55511118