JNJ 63533054

Key Product Details

Product Description

JNJ 63533054 is a potent and selective GPR139 agonist (EC₅₀ = 16 nM). Selective for GPR139 over a panel of GPCRs, ion channels and transporters, including GPR142. Brain and cell penetrant. Orally bioavailable.

Product Specifications for JNJ 63533054

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for JNJ 63533054

The following data is based on the product molecular weight 316.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.16 mL	15.78 mL	31.57 mL
5 mM	0.63 mL	3.16 mL	6.31 mL
10 mM	0.32 mL	1.58 mL	3.16 mL
50 mM	0.06 mL	0.32 mL	0.63 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Dvorak Identification and SAR of glycine benzamides as potent agonists for the GPR139 receptor. ACS Med.Chem.Lett. 2015 PMID: 26396690

Product Documents for JNJ 63533054