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JNJ 63533054

Catalog #: 5666 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5666/10
5666/50
JNJ 63533054 | CAS No. 1802326-66-4 | Orphan 7-TM Receptor Agonists
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Description: Potent and selective GPR139 agonist

Chemical Name: 3-Chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide

Purity: ≥98%

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Biological Activity

JNJ 63533054 is a potent and selective GPR139 agonist (EC50 = 16 nM). Selective for GPR139 over a panel of GPCRs, ion channels and transporters, including GPR142. Brain and cell penetrant. Orally bioavailable.

Technical Data

M.Wt:
316.78
Formula:
C17H17ClN2O2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
1802326-66-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Complete Your Experiment

Human GPR139 (NP_001002911) VersaClone cDNA
Cat # RDC2081

Background References

  1. Identification and SAR of glycine benzamides as potent agonists for the GPR139 receptor.
    Dvorak et al.
    ACS Med.Chem.Lett., 2015;6:1015

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VersaClone cDNA Plasmids

Human GPR139 (NP_001002911) VersaClone cDNA

RDC2081

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