Potent and selective GPR139 agonist (EC50
= 16 nM). Selective for GPR139 over a panel of GPCRs, ion channels and transporters, including GPR142. Brain and cell penetrant. Orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Identification and SAR of glycine benzamides as potent agonists for the GPR139 receptor.
Dvorak et al.
ACS Med.Chem.Lett., 2015;6:1015