JPS036

Tocris Bioscience | Catalog # 8085

Selective HDAC3 Degrader (PROTAC®)
Tocris Bioscience

Key Product Details

Description

Selective HDAC3 Degrader (PROTAC®)
View all Active Degraders »

Product Description

JPS036 is a selective HDAC3 Degrader (PROTAC®) (DC50 = 440 nM; Dmax = 77 %). JPS036 comprises a benzamide-based compound joined by a linker to a Von Hippel Lindau (VHL) E3 ligase ligand.

Negative control JPS016NC also available.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from the University of Leicester

Product Specifications for JPS036

Molecular Weight

940.19

Formula

C51H66FN7O7S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2S,4R)-N-[2-[[12-[[4-[(2-Aminophenyl)carbamoyl]phenyl]amino]-12-oxododecyl]oxy]-4-(4-methylthiazol-5-yl)benzyl]-1-[(S)-2-(1-fluorocyclopropan-1-ylcarbonylamino)-3,3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carboxamide

CAS Number

2669785-85-5

PubChem ID

156808378

InChI Key

NAADBQUVFJWCFU-XVYMMXEDSA-N

SMILES

O=C(C1(CC1)F)N[C@@H](C(C)(C)C)C(N2[C@@H](C[C@H](C2)O)C(NCC3=C(C=C(C4=C(N=CS4)C)C=C3)OCCCCCCCCCCCC(NC5=CC=C(C=C5)C(NC6=C(C=CC=C6)N)=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.8 20 with gentle warming

Preparing Stock Solutions for JPS036

The following data is based on the product molecular weight 940.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 5.32 mL 26.59 mL 53.18 mL
1 mM 1.06 mL 5.32 mL 10.64 mL
2 mM 0.53 mL 2.66 mL 5.32 mL
10 mM 0.11 mL 0.53 mL 1.06 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for JPS036

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for JPS036

For research use only

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