JQ dS-4

Tocris Bioscience | Catalog # 8152

BRG1/SMARCA4 Degrader (PROTAC®)
Tocris Bioscience

Key Product Details

Description

BRG1/SMARCA4 Degrader (PROTAC®)
View all Active Degraders »

Product Description

JQ dS-4 is a Brahma-related gene 1 (BRG1)/BRM/SMARCA4 Degrader (PROTAC®; DC50 range = 9 - 390 nM in glioma models and cell lines). Comprises a BRG1 inhibitor joined by a linker to a cereblon (CRBN) E3 ligase ligand. Completely degrades BRG1 after 48 and 72 hours in HSJD-DIPG007 and SU-DIPGXIIIP cells and reduces viability of a variety of cancer cell lines including H3K27M glioma, prostate, thyroid and salivary gland.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Product Specifications for JQ dS-4

Molecular Weight

719.16

Formula

C37H31ClN8O6

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

3-((4-(3-(2-Chloropyridin-4-yl)ureido)pyridin-2-yl)ethynyl)-N-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)benzamide

CAS Number

2688882-69-9

PubChem ID

156829976

InChI Key

IIYWQMYQROKRFZ-UHFFFAOYSA-N

SMILES

O=C(NC1=CC(C#CC2=CC=CC(C(NCCCCNC3=CC=CC(C(N4C5C(NC(CC5)=O)=O)=O)=C3C4=O)=O)=C2)=NC=C1)NC6=CC(Cl)=NC=C6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 71.92 100

Preparing Stock Solutions for JQ dS-4

The following data is based on the product molecular weight 719.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.39 mL 6.95 mL 13.91 mL
5 mM 0.28 mL 1.39 mL 2.78 mL
10 mM 0.14 mL 0.70 mL 1.39 mL
50 mM 0.03 mL 0.14 mL 0.28 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for JQ dS-4

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for JQ dS-4

For research use only

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