(+)-JQ1 PA

Catalog # Availability Size / Price Qty
(+)-JQ1 PA | CAS No. 2115701-93-2 | Degrader Building Blocks
1 Image
Description: Functionalized BET bromodomain inhibitor; 'click' target ligand for PROTACs

Chemical Name: (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-N-2-propyn-1-yl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide

Purity: ≥95%

Product Details

Biological Activity

(+)-JQ1 PA is a click-activated (alkyne) version of the BET bromodomain inhibitor (+)-JQ1 (Cat. No. 4499). Can be used as a precursor to a PROTAC® targeting BET bromodomains. Supplied with an alkyne functionalized handle for click conjugation to a linker/E3 ligase ligand. Can also be conjugated to fluorescent dyes for imaging aplications.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Click chemistry enables preclinical evaluation of targeted epigenetic therapies.
    Tyler et al.
    Science, 2017;356:1397

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