Home / Histone Demethylase Inhibitors / JQKD 82 dihydrochloride

JQKD 82 dihydrochloride

Catalog #: 7676 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7676/5
JQKD 82 dihydrochloride | Histone Demethylase Inhibitors
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Description: Selective inhibitor of lysine demethylase 5

Chemical Name: 2,4-Diisopropoxyphenyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate dihydrochloride

Purity: ≥98%

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Biological Activity

JQKD 82 dihydrochloride is cell-permeable, selective inhibitor of lysine demethylase 5 (KDM5). JQKD 82 does not show activity toward other KDMs; and it has selectivity for KDM5A over other KDM5 isoforms. JQKD 82 causes hypermethylation of H3K4me3, downregulation of MYC targets and RNAPII phosphorylation; it suppresses multiple myeloma cell (MM.1S) growth (IC50 = 0.42 µmol/L). JQKD 82-treated tumors display an increase in H3K4me3 levels and results in a reduction of MYC immuno-staining in NSG mice.

Technical Data

M.Wt:
573.56
Formula:
C27H40N4O5.2HCl
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute

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