Chemical Name: N-(1,3-Benzodioxol-5-ylmethyl)-1,2-dihydro-7-methoxy-2-oxo-8-(pentyloxy)-3-quinolinecarboxamide
Biological ActivityJTE 907 is a highly selective cannabinoid CB2 receptor inverse agonist. Binds with high affinity to rat, mouse and human CB2 receptors (Ki values are 0.38, 1.55 and 35.9 nM respectively). Produces anti-inflammatory effects in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB2 receptor.
Iwamura et al.
Involvement of cannabinoid CB2 receptor-mediated response and efficacy of cannabinoid CB2 receptor inverse agonist, JTE 907, in cutaneous inflammation in mice.
Ueda et al.
The cannabinoid CB2 receptor inverse agonist JTE-907 suppresses spontaneous itch-associated responses of NC mice, a model of atopic dermatitis.
Maekawa et al.
Citations for JTE 907
The citations listed below are publications that use Tocris products. Selected citations for JTE 907 include:
9 Citations: Showing 1 - 9
Cannabinoid WIN-55,212-2 mesylate inhibits tumor necrosis factor-α-induced expression of nitric oxide synthase in dorsal root ganglion neurons.
Authors: Tan and Cao
Int J Mol Med 2018;42:919
Cannabinoid WIN-55,212-2 mesylate inhibits ADAMTS-4 activity in human osteoarthritic articular chondrocytes by inhibiting expression of syndecan-1.
Authors: Kong Et al.
Mol Cell Neurosci 2016;13:4569
Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release.
Authors: Wang Et al.
J Clin Invest 2016;126:4527
Regional effects of endocannabinoid, BDNF and FGF receptor signalling on neuroblast motility and guidance along the rostral migratory stream.
Authors: Zhou Et al.
Br J Pharmacol 2015;64:32
HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity.
Authors: Vicente-Sánchez Et al.
Mol Brain 2013;6:42
Cannabinoid receptors couple to NMDA receptors to reduce the production of NO and the mobilization of zinc induced by glutamate.
Authors: Sánchez-Blázquez Et al.
Antioxid Redox Signal 2013;19:1766
Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors.
Authors: Marini Et al.
Br J Pharmacol 2013;169:887
Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery.
Authors: Mair Et al.
Br J Pharmacol 2010;161:176
WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.
Authors: Price Et al.
Eur J Neurosci 2009;29:2177
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Orally administered JTE-907 (10 mg/kg) in a murine allergic contact dermatitis model.