Catalog Number: 2479
Chemical Name: N-(1,3-Benzodioxol-5-ylmethyl)-1,2-dihydro-7-methoxy-2-oxo-8-(pentyloxy)-3-quinolinecarboxamide
Biological Activity
Highly selective cannabinoid CB2 receptor inverse agonist. Binds with high affinity to rat, mouse and human CB2 receptors (Ki values are 0.38, 1.55 and 35.9 nM respectively). Produces anti-inflammatory effects in vivo.
Technical Data
  • M.Wt:
    438.48
  • Formula:
    C24H26N2O6
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    282089-49-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB2 receptor.
    Iwamura et al.
    J.Pharmacol.Exp.Ther., 2001;296:420
  2. Involvement of cannabinoid CB2 receptor-mediated response and efficacy of cannabinoid CB2 receptor inverse agonist, JTE 907, in cutaneous inflammation in mice.
    Ueda et al.
    Eur.J.Pharmacol., 2005;520:164
  3. The cannabinoid CB2 receptor inverse agonist JTE-907 suppresses spontaneous itch-associated responses of NC mice, a model of atopic dermatitis.
    Maekawa et al.
    Eur.J.Pharmacol., 2006;542:179

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