JTE 907

Catalog # Availability Size / Price Qty
2479/10
2479/50
JTE 907 | CAS No. 282089-49-0 | Cannabinoid R2 / CB2 Inverse Agonists
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Description: Selective CB2 receptor inverse agonist

Chemical Name: N-(1,3-Benzodioxol-5-ylmethyl)-1,2-dihydro-7-methoxy-2-oxo-8-(pentyloxy)-3-quinolinecarboxamide

Purity: ≥99%

Product Details
Citations (9)
Supplemental Products
Reviews

Biological Activity

Highly selective cannabinoid CB2 receptor inverse agonist. Binds with high affinity to rat, mouse and human CB2 receptors (Ki values are 0.38, 1.55 and 35.9 nM respectively). Produces anti-inflammatory effects in vivo.

Technical Data

M.Wt:
438.48
Formula:
C24H26N2O6
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
282089-49-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for JTE 907

The citations listed below are publications that use Tocris products. Selected citations for JTE 907 include:

9 Citations: Showing 1 - 9

  1. Cannabinoid WIN-55,212-2 mesylate inhibits tumor necrosis factor-α-induced expression of nitric oxide synthase in dorsal root ganglion neurons.
    Authors: Tan and Cao
    Int J Mol Med  2018;42:919
  2. Cannabinoid WIN-55,212-2 mesylate inhibits ADAMTS-4 activity in human osteoarthritic articular chondrocytes by inhibiting expression of syndecan-1.
    Authors: Kong Et al.
    Mol Cell Neurosci  2016;13:4569
  3. Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release.
    Authors: Wang Et al.
    J Clin Invest  2016;126:4527
  4. Regional effects of endocannabinoid, BDNF and FGF receptor signalling on neuroblast motility and guidance along the rostral migratory stream.
    Authors: Zhou Et al.
    Br J Pharmacol  2015;64:32
  5. HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity.
    Authors: Vicente-Sánchez Et al.
    Mol Brain  2013;6:42
  6. Cannabinoid receptors couple to NMDA receptors to reduce the production of NO and the mobilization of zinc induced by glutamate.
    Authors: Sánchez-Blázquez Et al.
    Antioxid Redox Signal  2013;19:1766
  7. Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors.
    Authors: Marini Et al.
    Br J Pharmacol  2013;169:887
  8. Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery.
    Authors: Mair Et al.
    Br J Pharmacol  2010;161:176
  9. WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.
    Authors: Price Et al.
    Eur J Neurosci  2009;29:2177

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