Chemical Name: 2-Isopropylphenyl(2-(naphthalen-2-yl)ethyl)carbamate
Biological ActivityPotent and selective inhibitor of the serine hydrolase enzyme KIAA1363 (AADACL1) (IC50 = 20 nM in mouse brain). Impairs migration, invasion, survival and tumor growth of prostate cancer cell lines in vivo. Reduces monoalkylglycerol ether (MAGE) levels.
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A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis.
Chang et al.
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