Potent and selective inhibitor of the serine hydrolase enzyme KIAA1363 (AADACL1) (IC50
= 20 nM in mouse brain). Impairs migration, invasion, survival and tumor growth of prostate cancer cell lines in vivo
. Reduces monoalkylglycerol ether (MAGE) levels.
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A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis.
Chang et al.