JX 401

Key Product Details

Product Description

JX 401 is a potent, reversible inhibitor of p38α that displays no activity on the p38γ isoform (IC₅₀ values are 32 nM and > 10 μM respectively). Inhibits the differentiation of myoblasts to myotubes in mammalian cells in culture.

Product Specifications for JX 401

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for JX 401

The following data is based on the product molecular weight 355.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	3.75 mL	18.75 mL	37.51 mL
3.75 mM	0.75 mL	3.75 mL	7.50 mL
7.5 mM	0.38 mL	1.88 mL	3.75 mL
37.5 mM	0.08 mL	0.38 mL	0.75 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Friedmann JX401, a p38α inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast. Mol.Pharmacol. 2006 PMID: 16847144

Product Documents for JX 401