Chemical Name: 1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine
Biological ActivityJX 401 is a potent, reversible inhibitor of p38α that displays no activity on the p38γ isoform (IC50 values are 32 nM and > 10 μM respectively). Inhibits the differentiation of myoblasts to myotubes in mammalian cells in culture.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
JX401, a p38α inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast.
Friedmann et al.
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