JZL 184

  ( 5 citations )    
Product Datasheet
Catalog Number:3836
Chemical Name:4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 4-nitrophenyl ester
Product Details
Citations (5)
Reviews
Biological Activity
Potent and selective MAGL inhibitor. Blocks hydrolysis of the endocannabinoid 2-arachidonyl glycerol (2-AG) in vivo in the mouse brain (IC50 = 8 nM). Potentiates depolarization-induced suppression of excitability in cerebellar Purkinje neurons. Exhibits >300-fold selectivity for MAGL over FAAH in vitro. Attenuates nociception in neuropathic and inflammatory pain models. Also reduces free fatty acid levels in primary tumors.
Technical Data
  • M.Wt:
    520.49
  • Formula:
    C27H24N2O9
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    1101854-58-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from The Scripps Research Institute.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for JZL 184 include:

5 Citations: Showing 1 - 5
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  1. Endocannabinoids Mediate Muscarinic Acetylcholine Receptor-Dependent Long-Term Depression in the Adult Medial Prefrontal Cortex.
    Authors: Martin Et al.
    Stem Cells Dev  2015;9:457
  2. Inhibiting endocannabinoid biosynthesis: a novel approach to the treatment of constipation.
    Authors: Bashashati Et al.
    Br J Pharmacol  2015;172:3099
  3. Experimental cannabinoid 2 receptor-mediated immune modulation in sepsis.
    Authors: Sardinha Et al.
    Front Cell Neurosci  2014;2014:978678
  4. The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG.
    Authors: Valdeolivas Et al.
    Cell Death Dis  2013;4:e862
  5. CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release.
    Authors: Malenczyk Et al.
    J Biol Chem  2013;288:32685

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