JZL 184

Catalog # Availability Size / Price Qty
3836/10
3836/50
JZL 184 | CAS No. 1101854-58-3 | Monoacylglycerol Lipase Inhibitors
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Description: Potent MAGL inhibitor

Chemical Name: 4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 4-nitrophenyl ester

Purity: ≥98%

Product Details
Citations (7)
Reviews

Biological Activity

Potent and selective MAGL inhibitor. Blocks hydrolysis of the endocannabinoid 2-arachidonyl glycerol (2-AG) in vivo in the mouse brain (IC50 = 8 nM). Potentiates depolarization-induced suppression of excitability in cerebellar Purkinje neurons. Exhibits >300-fold selectivity for MAGL over FAAH in vitro. Attenuates nociception in neuropathic and inflammatory pain models. Also reduces free fatty acid levels in primary tumors.

Technical Data

M.Wt:
520.49
Formula:
C27H24N2O9
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1101854-58-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from The Scripps Research Institute.

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